RESUMO
A positive dynamics of the course of glomerulonephritis under the effect of pathogenetic therapy evaluated in 140 patients was accompanied by a statistically valid reduction of glycoseaminoglycanes in the urine. This allows to use these indices as adjunctive criteria of treatment efficiency, especially in patients with chronic forms of the disease.
Assuntos
Glomerulonefrite/urina , Glicosaminoglicanos/urina , Doença Crônica , Ciclofosfamida/uso terapêutico , Avaliação de Medicamentos , Glomerulonefrite/tratamento farmacológico , Glomerulonefrite/epidemiologia , Glomerulonefrite/etiologia , Humanos , Indometacina/uso terapêutico , Indução de Remissão , Estudos RetrospectivosAssuntos
Arginina/metabolismo , Glomerulonefrite/enzimologia , Glutamina/metabolismo , Adolescente , Adulto , Arginina/análise , Doença Crônica , Feminino , Glutamina/análise , Humanos , Rim/enzimologia , Falência Renal Crônica/enzimologia , Masculino , Pessoa de Meia-Idade , Síndrome Nefrótica/enzimologiaAssuntos
Glomerulonefrite/terapia , Rejeição de Enxerto , Transplante de Rim , Animais , Cães , Transplante HomólogoRESUMO
Among all the glutamine deaminating enzymes the highest activity was exhibited by phosphate-dependent glutaminase (72% of the total activity) in kidney cortex and blood serum of healthy dogs and by phosphate-independent glutaminase (47% of the total activity)--in liver tissue. A distinct decrease in the activity of both isoforms of glutaminase I (phosphate-dependent and phosphate-independent enzymes) and of glutaminase II (pyruvate-dependent enzyme) occurred in kidney under conditions of acute and chronic kidney insufficiency. The phosphate-independent glutaminase activity was decreased and, by contrast, activities of phosphate- and pyruvate-dependent glutaminases were increased in liver tissue under the conditions of acute kidney insufficiency. In blood serum under conditions of acute and chronic insufficiency the glutaminase I (both forms) activity was distinctly dcreased, but the glutaminase II activity had a marked trend to elevation. Possible mechanisms responsible for an alteration of glutamine deaminating enzymes in kidney, liver tissue and blood serum of dogs under acute and chronic kidney insufficiency are discussed.