[A CASE OF IMPORT OF GENOTYPE 4 HEPATITIS E VIRUS INTO RUSSIA].

AIM: Description of the first documented case of imported hepatitis E, associated with geno- type 4 of HEV and introduced from southern France. MATERIALS AND METHODS: Clinical, epidemio- logic and laboratory analysis of the imported case of disease of hepatitis E was carried out. Phylogenetic analysis of nucleotide sequences of HEV isolate, taken from the patient, was carried out. RESULTS: Epidemiologic analysis allowed to assume imported character of the detected case of HEV-infection. Comparative analysis ofnucleotide sequences of regions ofthe open reading frame 2 (300 nt) and open reading frame 1 (721 nt) of HEV genome, isolated from the patient, showed identity of this isolate with variants of genotype 4 HEV, isolated in France in 2009 - 2011 from patients with autochthonous hepatitis E. CONCLUSION: The results obtained confirm the case of import into Russia of genotype 4 HEV from south-eastern France (Corsica), where spread of this virus genotype is observed in recent years.

[Depression of an increase of fatty acids in the blood of monkeys during stress by means of the administration of prostaglandin]. / Ugnetenie vozrastaniia urovniia zhirnykh kislot v plazme obez'ian pri stresse s pomoshch'iu vvedeniia prostaglandina

In examining the level and composition of free fatty acids in the blood plasma of monkeys there were revealed distinct shifts following stress (immobilization) which were prevented by a single administration of prostaglandine E2 directly before the stress. The authors analyze the role of prostaglandines in the capacity of a factor participating in the mechanism of a reverse association, and thus, limiting the lipolytic effect of neuromediators and hormones markedly secreted in case of stress.