RESUMO
The history of autoimmune thyroiditis (AIT) and its role in pathophysiology of transition from adolescent hypothalamic syndrome (obesity with rose striae) into early metabolic syndrome is reviewed. Marfanoid phenotype and chronic disequilibrium between local, autacoid-mediated and systemic, hormone-mediated regulation, typical for inherited connective tissue disorders, may promote this transition. Pathogenetic roles of hyperprolactinemia and cytokine misbalance are evaluated and discussed in its pathogenesis.
RESUMO
A simplified method of synthesis of triterpene l,2-trans-glycosides was developed using the glycosylation of glycyrrhetic acid (GLA) and 18,19-dehydro-GLA by beta-pyranose peracetates in the presence of SnCl(4) and molecular sieves 4 A. The synthesized glycosides exhibited hepatoprotective activity toward the human hepatoma HepG2 cell line on the model of alcohol hepatitis and decreased the level of TNF-alpha protein.
Assuntos
Glicosídeos/síntese química , Glicosídeos/farmacologia , Ácido Glicirrízico , Hepatite Alcoólica/tratamento farmacológico , Hepatócitos/metabolismo , Triterpenos/síntese química , Triterpenos/farmacologia , Linhagem Celular Tumoral , Glicosídeos/química , Hepatócitos/patologia , Humanos , Modelos Biológicos , Triterpenos/química , Fator de Necrose Tumoral alfa/biossínteseRESUMO
Noradrenaline injected into cerebral lateral ventricles was found to change the temperature homeostasis in white rats. The fall of rectal temperature, the rise of brown adipose tissue temperature and oxygen consumption occurred within 25-30 min after the injection. Preliminary adaptation to cold increased the effect of noradrenaline. The beta-adrenergic blockade of cerebral structures by propranolol altered the noradrenaline effect: both the rise of brown adipose tissue temperature and the oxygen consumption increase do not occur. This effect is more obvious in cold-adapted animals. The adaptation to cold seems to increase the sensitivity of central adrenergic structures to noradrenaline, central beta-adrenoreceptors being mainly responsible for the effect of noradrenaline (the rise of brown adipose tissue temperature and the oxygen consumption increase) on the thermoregulation.
