RESUMO
Peripheral blood lymphocytes were electron microscopically studied in patients with disseminated drug-sensitive and drug-resistant pulmonary tuberculosis before and during specific antituberculous chemotherapy. There was a tendency for an increase in the count of lymphocytes with membranous morphostructural changes during the therapy, which was more clearly defined in the drug-resistant type of the infectious process. It is suggested that antituberculous drugs have a damaging effect on the membrane of immunocompetent blood cells.
Assuntos
Antituberculosos/efeitos adversos , Linfócitos/efeitos dos fármacos , Linfócitos/ultraestrutura , Tuberculose Resistente a Múltiplos Medicamentos/imunologia , Tuberculose Pulmonar/imunologia , Adulto , Idoso , Antituberculosos/administração & dosagem , Feminino , Humanos , Contagem de Linfócitos , Masculino , Microscopia Eletrônica , Pessoa de Meia-Idade , Tuberculose Resistente a Múltiplos Medicamentos/tratamento farmacológico , Tuberculose Pulmonar/tratamento farmacológicoRESUMO
Twenty-four children aged 3-15 years were examined, 16 of these with cutaneous and articulo-cutaneous hemorrhagic vasculitis (HV) and 8 normal controls. The patients were divided into 2 groups: 10 patients treated by basic therapy and 6 children whose treatment protocols were supplemented by membranoprotector locheine. The children were repeatedly examined 1 month after discharge from hospital. Scanning electron microscopy of peripheral blood erythrocytes provides valuable diagnostic data on erythrocyte membrane morphology and function in children with HV and can serve as a method for monitoring the efficiency of new approaches to therapy of this disease.
Assuntos
Eritrócitos/ultraestrutura , Vasculite por IgA/sangue , Microscopia Eletrônica de Varredura , Adjuvantes Imunológicos/uso terapêutico , Adolescente , Antioxidantes/uso terapêutico , Criança , Pré-Escolar , Interpretação Estatística de Dados , Membrana Eritrocítica/ultraestrutura , Seguimentos , Humanos , Vasculite por IgA/diagnóstico , Vasculite por IgA/terapia , Monitorização Fisiológica , Extratos Vegetais/uso terapêutico , Fatores de TempoRESUMO
Electron microscopic study of the surface architectonics and ultrastructure of the peripheral blood erythrocytes in 25 children with insulin-dependent diabetes mellitus (IDDM) revealed that the decrease of the count of disk-shaped cells, increased count of transitional and degenerative forms, and alteration of their ultrastructure. Traditional therapy failed to completely normalized these characteristics over the entire follow-up.
