RESUMO
The Finnish-Russian collaboration on rabies control began in 2000. This data summarizes the results of the scientific part of the programme, including rabies monitoring in Russia and the molecular epidemiological studies with field viruses.
Assuntos
Encéfalo/virologia , Vacina Antirrábica/administração & dosagem , Vírus da Raiva/classificação , Raiva/veterinária , Animais , DNA Viral/análise , Finlândia , Heterogeneidade Genética , Genótipo , Humanos , Filogenia , Raiva/epidemiologia , Raiva/prevenção & controle , Raiva/virologia , Vírus da Raiva/genética , Vírus da Raiva/isolamento & purificação , Federação Russa , Vigilância de Evento Sentinela/veterinária , Zoonoses/virologiaRESUMO
The RV-97 rabies virus vaccine strain is widely used in Russia as a component of the live attenuated oral anti-rabies vaccine "Sinrab". This vaccine has also been used in some other countries, such as Kazakhstan, Belarus, and Ukraine. Entire genome sequencing is an effective tool for studying the genetic properties of virus strains. In this study, a simple technique for obtaining the entire genome sequence of the rabies virus was used. The entire genome sequence and the deduced amino acid sequences of the major viral proteins were compared with those of other rabies vaccine virus strains. The RV-97 strain forms a separate phylogenetic branch and seems to be phylogenetically more related to the group of Japanese vaccine strains. It also contains several unique amino acid changes in known immunodominant sites of G and P proteins.
Assuntos
Genoma Viral , Vacina Antirrábica/química , Vírus da Raiva/genética , Sequência de Aminoácidos , Antígenos Virais/química , Antígenos Virais/genética , Japão , Dados de Sequência Molecular , Fosfoproteínas/química , Fosfoproteínas/genética , Filogenia , Vacina Antirrábica/genética , Vírus da Raiva/classificação , Federação Russa , Análise de Sequência , Homologia de Sequência de Aminoácidos , Proteínas do Envelope Viral/química , Proteínas do Envelope Viral/genética , Proteínas Virais/química , Proteínas Virais/genéticaRESUMO
The most complicated situation concerning rabies is seen in the Saratov region. The basic reservoir of rabies in this region is wild carnivores. A study was conduted in three districts of the Saratov region to define the efficiency of measures taken with the "Sinrab" rabies vaccine containing "RV-97" used for oral immunisation of wild animals. As a result of the experiment it was established that specific prevention of rabies in wildlife in enzootic territories resulted in a decrease of rabies cases.
Assuntos
Carnívoros , Vacina Antirrábica/farmacologia , Raiva/prevenção & controle , Vacinação , Administração Oral , Animais , Animais Domésticos , Animais Selvagens , Carnívoros/virologia , Raiva/epidemiologia , Raiva/veterinária , Estudos Retrospectivos , Federação Russa , Zoonoses/epidemiologia , Zoonoses/virologiaRESUMO
Molecules of foot-and-mouth disease (FMD) virus interacting with susceptible porcine kidney cells block their receptors and inhibit FMD virus infection. Adsorption of inactivated virus by cells is rapid, reversible, and type-specific. Efficacy of cell receptor blocking and protection from FMD depends on the dose of specific antigen and adequate saturation.
