RESUMO
Light exposure (6000 lux, 6 h) caused reactive changes in rat retinal pigmented epithelium and radial glia on day 1. Foci of lesions with virtually complete absence of the layers formed by neurosensory cells appeared on day 7. The number of destructively changed radial gliocytes in these foci was by one order of magnitude higher than in the control. Carovertin reduced destruction of pigmented epithelium and radial glia and reduced the area of lesion foci.
Assuntos
Ácido Ascórbico/farmacologia , Luz/efeitos adversos , Neuroglia/efeitos dos fármacos , Neuroglia/efeitos da radiação , Epitélio Pigmentado Ocular/efeitos dos fármacos , Epitélio Pigmentado Ocular/efeitos da radiação , Quercetina/análogos & derivados , beta Caroteno/farmacologia , Animais , Flavonóis/farmacologia , Masculino , Quercetina/farmacologia , RatosRESUMO
Experiments on rats showed that high-intensity light exposure (6000 lux, 6 h) caused focal injuries in the retina. The most sensitive structures were neurosensory cells, pigmented epithelium, radial gliocytes, and choroid capillaries. Injection of ascovertin led to disappearance of foci of injuries, limited blood supply disorders in the retina, and destruction of neurosensory and glial cells.
