[Dopamine antibodies as neuromodulators of behavioral reactions in mice of different genotypes]. / Antitela k dofaminu kak neiromoduliatory povedencheskikh reaktsii myshei raznykh genotipov.

A possibility of the long-term modification of inborn behavioral features of different mice genotypes (C57B1/6 and BALB/c) by active immunization with dopamine-bovine serum albumin conjugate was investigated. Significant interstrain differences were found in the effects of dopamine antibodies on the open-field behavior and the content of neurotransmitters in the brain cortex and striatum. It was shown that the active immunization of mice to dopamine produces an increase in the functional activity of brain dopamine receptors. The extent, to which this increase is pronounced, is genotype-dependent.

[Modulation of behavior of mice of different genotypes by serotonin antibodies]. / Moduliatsiia antitelami k serotoninu povedencheskikh reaktsii myshei raznykh genotipov.

The effect of active immunization with conjugated serotonin-protein on the "open-field" behaviour and passive avoidance conditioning was studied in genetically different mice strains (C57BL/6 and BALB/c). The obtained immunophysiological effects of serotonin antibodies depended on genetically determined characteristics of animal behaviour. Serotonin antibodies altered rearing and crossings of the "open-field" center and retention of passive avoidance learning in C57BL/6 mice. The active immunization with conjugated serotonin-protein of BALB/c mice resulted in modulation of the "open-field" latency and both training and testing of passive avoidance behaviour.

[Dopamine antibodies: effect on the "open field" behavior, pain sensitivity, monoamine levels in the central nervous system, and functional activity of immunocytes in C57Bl/6 mice]. / Antitela k dofaminu: deistvie na povedenie v "otkrytom pole", bolevuiu chuvstvitel'nost', soderzhanie monoaminov v TsNS i funktsional'nuiu aktivnost' immunotsitov myshei linii C57Bl/6.

Dopamine antibodies (AB) were singularly injected to C57B1/6 mice intraperitoneally. The locomotor activity in the open field was suppressed for 5 days in the majority of the animals. Hyperalgesia revealed 1.5 h and 1 day after the AB injection changed for analgesia on the 5th day. A sharp reduction of the brain level of dopamine and its metabolite was revealed 1 and 5 days after the AB injection, the serotonin content was increased within 1 day and decreased within 5 days after the injection. No action of the AB on cells of the immune system was observed. The possible mechanisms of the AB neurotropic action are discussed.

[The effect of serotonin antibodies on the behavior of C57Bl/6 mice in an open field and on the level of monoamines in the brain structures]. / Vliianie antitel k serotoninu na povedenie myshei C57Bl/6 v otkrytom pole i soderzhanie monoaminov v strukturakh golovnogo mozga.

Mice of C57BL/6 strain were singly injected intraperitoneally with antibodies (AB) to serotonin (5-HT). The "open-field" testing in different periods after the AB injection revealed a depression of behavior within 1.5 h which changed for activation within 1 day and, again, depression within 5 days after the injection. The analysis of neurotransmitter content in the sensorimotor cortex and hypothalamus revealed increased levels of serotonin and, especially, dopamine in the cortex within 1 day. The cortex serotonin level within 5 days was also increased. The possible mechanisms are discussed of neurotropic action of AB to 5-HT.

[Comparative analysis of the action of antibodies to dopamine and serotonin on the functional activity of T- and B-lymphocytes and peritoneal macrophages]. / Sravnitel'nyi analiz deistviia antitel k dopaminu i serotoninu na funktsional'nuiu aktivnost' T-, B-limfotsitov i peritoneal'nykh makrofagov.

As shown in experiments on mice C57B1/6, systemic intraperitoneal injection of serotonin antibodies in a dose 25 mg/kg or their introduction into cell culture in a dose 10(-7)M attenuates proliferative response of lymphocytes on PWM-induced stimulation, while functional activity of macrophages is stimulated. Antibodies to dopamine neither in systemic nor in cell culture introduction cause noticeable changes in lymphocytes proliferative response to their PWM and ConA mitogen stimulation. Phagocytic activity of peritoneal macrophages was also unchanged.

[A comparative analysis of the effects of the systemic and intraventricular administration of serotonin antibodies on the behavioral reactions and nociceptive sensitivity in animals]. / Sravnitel'nyi analiz éffektov sistemnogo i vnutrizheludochkovogo vvedeniia antitel k serotoninu na povedencheskie reaktsii i notsitseptivnuiu chuvstvitel'nost' zhivotnykh.

The antibodies to serotonin modulate behavioural reactions of animals depending on the mode of administration (intracerebroventricular or intraperitoneal) and the testing time. Intraventricular injection induces inhibition of behavioural activity within 1--2 hours. Systemic injection produces a biphasic effect on the serotoninergic system, i. e., the activation in the early period and the steady inhibition later. Effects of the intraperitoneally injected serotonin antibodies on the CNS are probably mediated either by serotonin binding in blood or by involvement of neurotrophic factors of the immune system. Both ways of administration of the serotonin antibodies result in late hyperalgesia.

[The natural killer activity and indices of the interferon status of patients with recurrent genital herpes being treated with ridostin]. / Aktivnost' estestvennykh killerov i pokazateli interferonovogo statusa u bol'nykh retsidiviruiushchim gerpesom genitalii pri lechenii ridostinom.

Natural killer cell activity (NK) in parallel with the interferon (IFN)-alpha and IFN-gamma production as well as with a level of IFN in the blood serum were studied in 15 patients with relapsing herpes genitalis (RHG). Rhidostin, well known as an IFN-alpha inducer, was used in a dose of 2 mg once daily for 3 days subcutaneously up to a total dose of 8 mg of the preparation. The NK cell activity and IFN-alpha production were shown to decrease in RHG more significantly in the stage of remission than during the relapse of the process. As a result of rhidostin therapy the NK cell activity was restored simultaneously with the positive clinical effect of the drug. Rhidostin was found to be an efficient modifier of the IFN system functioning in patients with RHG. The above data allow a conclusion that rhidostin exhibiting an independent antiviral and immunostimulating action might be useful in patients with a remission of RHG for prevention of its relapses.