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The COVID-19 pandemic caused that most countries established the closure of many beaches, affecting the scientific monitoring of thousands of coastal sectors. This article shows the status of beach litter in South America before and after COVID-19 closure. The data were obtained during the years 2019, 2020 and 2022 on 25 beaches using a technique BLAT-QQ. The results show that cigarette butts were the most frequent type of litter, meanwhile Brazil should improve cleanliness of general gross litter and gross polystyrene. Colombia gross vegetation litter and small vegetation litter, and Ecuador organic litter from animals. The results shown in qualitative and quantitative manner facilitate their understanding for managers, scholars and activists interested on beach litter monitoring. This baseline is useful to analyse regional and worldwide marine litter trends with the purpose to start or restart monitoring of tourist beaches from a science-based method.
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COVID-19 , Resíduos , Humanos , Resíduos/análise , Monitoramento Ambiental/métodos , Pandemias , Plásticos , Praias , BrasilRESUMO
Urban tourist beach ecosystems provide the essential service of recreation. These ecosystems also support critical ecological functions where biodiversity conservation is not usually a priority. The sudden lockdown due to the COVID-19 pandemic created a unique opportunity to evaluate the effects of human absence in these urban-coastal ecosystems. This study examined bioindicators from 29 urban tourist beaches in seven Latin-American countries and assesses their response to lockdown about some relevant anthropogenic stressors such as pollution, noise, human activities, and user density. The presence of animals and plants, as well as the intensity of stressors, were assessed through a standardized protocol during lockdown conditions. Additionally, the environmental conditions of the beaches before and during lockdown were qualitatively compared using multivariate non-parametric statistics. We found notable positive changes in biological components and a clear decrease in human stressors on almost all the beaches. Dune vegetation increased on most sites. Similarly, high burrow densities of ghost crabs were observed on beaches, except those where cleaning activity persisted. Because of the lockdown, there was an exceptionally low frequency of beach users, which in turn reduced litter, noise and unnatural odors. The observed patterns suggest that tourist beaches can be restored to natural settings relatively quickly. We propose several indicators to measure changes in beaches once lockdown is relaxed. Adequate conservation strategies will render the recreational service of tourist beaches more environmental-friendly.
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Human interventions on coastal areas are always causing environmental impact; however, most of the times inventories of those interventions are possibly not well structured, and surely without a specific standard. The raw data presented shows an exhaustive and systematic revision of satellite images on 1700â¯km of the Caribbean coast of Colombia, where 2743 human interventions were identified. These interventions are classified in 38 categories in order to assess their environmental impact at a regional scale. The filtered data shows the environmental impact obtained for each category and the values allotted to each of the four parameters used for this evaluation. Moreover, the data is filtered for each of the five environmental coastal units in which the Caribbean coast of Colombia is divided by national regulations. Finally, the filtered and processed data shows the analysis done to obtain the graphical results of a previously paper (An evaluation of human interventions in the anthropogenically disturbed Caribbean Coast of Colombia [1]). Therefore, this dataset comprises three spreadsheets (xlsx) and two geographical files (kmz), which are ready to be used for any researcher, decision maker, land planner or practitioner interested in making further analysis on environmental impact assessment in coastal areas. Additionally, the dataset is carefully organised for educational exercises in such a manner that professors or lecturers can repeat the same steps in this study area or in their own, from the inventory to the final results.
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Litter presence was assessed on the entire Cuban coastline, and includes 99 beaches from all Cuban regions, during field work carried out in 2012 and 2015. A standard method verified in several countries was applied, which classified beaches for nine types of litter into four grades (A-excellent to D-poor). Almost half of the Cuban beaches obtained excellent cleanliness scores, although many needed to be better managed. In this baseline, the most common types of residue were general litter (8% grade D and 35% grades B/C) and potentially harmful litter (<68% with grade A). Resort beaches and those with international visitors showed the best litter management. Tourism Impacts seems to be related to visitor origin therefore choices to develop sustainable tourism in rural and village beaches (64%) appears low, if beach cleaning gross investment is focused on resort beaches (24%). Finally, this paper highlights geographical distribution and types of litter patterns.
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Praias , Poluição Ambiental , Cuba , Humanos , Recreação , ViagemRESUMO
INTRODUCTION: Media are main allies to encourage donation and transplantation. We sought to quantify the presence in the media of the topic "Donation and transplantation (D/Tx)" during the period 2005 to 2007 and to determine the relationship between the volume of information issued by the media and indexes related to the topic. METHODS: We conducted a systematic recording of the news on the topic of D/Tx in print, radio, and television during 2005 to 2007. RESULTS: There was an increased presence in the media by 100% in 2005 and 2006, and by 200% in 2007. The presence in print media was greater than radio (249 +/- 31.5 vs 131 +/- 5.49; P = .05) or television (249 +/- 31.5 vs 92 +/- 7.12; P = .01). We observed a positive correlation between the total number of contacts versus the number of registered volunteer donors (R(2) = 0.9713) and number of contacts versus total number of transplants from cadaveric donors (CTX; R(2) = 0905). The index CTX per million population increased by 30% (2006 vs 2005) and 100% (2007 vs 2005). The percent of family refusals fell from 41% in 2005 to 34% in 2006 and to 31% in 2007. The rate of donors per million population grew steadily from 1.8 in 2005 to 2.3 in 2006, and to 3.6 in 2007. CONCLUSION: The sustained increase in D/Tx briefing as a strategy of Sistema de Procura de Organos y Tejidos has helped to foster a positive perception that is reflected in the increased rate of donation and transplantation in Venezuela.
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Atitude , Meios de Comunicação , Transplante de Órgãos/estatística & dados numéricos , Percepção , Obtenção de Tecidos e Órgãos/estatística & dados numéricos , Cadáver , Humanos , Rádio , Publicações Seriadas , Comportamento Social , Televisão , Doadores de Tecidos/estatística & dados numéricos , Venezuela , Voluntários/estatística & dados numéricosRESUMO
OBJECTIVE: To identify the variables that influenced brain-dead donor family groups to refuse donation. METHODS: The Tissue and Organ Procurement System in Venezuela designed a tool to register some phases of a family interview performed by transplant coordinators. This tool analyzed three phases. The first phase of the interview allowed the coordinator to evaluate the communication quality with the family group during a brain-death notification. The second phase assessed how families understood this notification, and the third phase identified the family grief sequence. Among the 186 interviews during 2007 to procure tissues and organs for transplantation, 37.63% (n = 70) concluded as family refusals. A retrospective study sought to analyze these results. RESULTS: The average time between notification of brain death and the first approach to the family was 8.78 hours. Setting a place for interviews was done in 91.10% of cases. Previous knowledge about donation was seen in only 53.33% of cases. The main phase of family grief identified was denial (80%). The five reasons for family denial were: absolute denial, family disagreement, uncertainty about the destination of the donated organs and tissues, fear about deformation of the donor's body, and lack of acceptance of brain death. CONCLUSIONS: Brain-death notification produced a deep sadness among family groups. There was a lack of knowledge regarding donation of tissues and organs. It was impossible to quantify the time needed by families to understand and accept brain death and to identify the grief sequence in order to avoid family refusals.
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Morte Encefálica , Família , Recusa de Participação , Doadores de Tecidos/estatística & dados numéricos , Obtenção de Tecidos e Órgãos/organização & administração , Atitude Frente a Morte , Causas de Morte , Humanos , Consentimento Livre e Esclarecido , Entrevistas como Assunto , Relações Profissional-FamíliaRESUMO
Latin America, a region composed of a series of neighboring countries that share their history, Latin ancestry and language (Spanish or Portuguese), includes Mexico, Central America, the Spanish Caribbean islands, and South America. The Latin-American Dialysis and Kidney Transplantation Registry, which has been operative since 1991, collects data from 20 countries (Argentina, Brazil, Bolivia, Chile, Colombia, Costa Rica, Cuba, Ecuador, El Salvador, Guatemala, Honduras, Mexico, Nicaragua, Panama, Paraguay, Peru, Puerto Rico, Dominican Republic, Venezuela and Uruguay), where 97% of Latin Americans live. The prevalence of renal replacement therapy (RRT) has increased from 119 patients per million (pmp) in 1991 to 478.2 in 2005 (147,158 patients [57%] on chronic hemodialysis, 58,251 [23%] on peritoneal dialysis and 52,565 [20%] living with a functioning kidney graft). The incidence rate also increased from 27.8 pmp in 1992 to 167 in 2005. The increment in prevalence and incidence occurred in all Latin- American countries. The transplantation rate increased from 3,7 pmp in 1987 to 15 pmp in 2005 (7,968 kidney transplants performed this year, the cumulative number being 98,415). Access to RRT was available for every patient diagnosed with end-stage renal disease only in Argentina, Brazil, Chile, Cuba, Puerto Rico, Venezuela and Uruguay. In Latin America, the incidence and prevalence of RRT increased year by year. Only in some countries is access to RRT available to 100% of diagnosed patients. Detection and prevention programs for chronic kidney disease are needed in the region. Meanwhile, access to RRT has to be improved for everybody who needs it.
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Falência Renal Crônica/terapia , Transplante de Rim/estatística & dados numéricos , Sistema de Registros , Diálise Renal/estatística & dados numéricos , Humanos , América LatinaRESUMO
Recently in Latin America, there has been a strong influence of the "Spanish model" of organ procurement. In 2001, The "Punta Cana Group" was created by Latin American transplantation coordinators with the objective of registering and improving the system of donation and procurement. In many countries there is no universal financial support from the government for medical treatment, including dialysis and transplantation. In other countries there is complete financial support for all of the population, including immunosuppressive drugs. Practically all countries have transplantation laws that follow ethical concepts, such as brain death diagnosis criteria, forms of consent, criteria of allocation, and inhibition of commerce. The rate of potential donors notified in countries that perform transplantations with deceased donors varied from 6 to 47 per million population yearly (pmp/y); The rate of effective donors varied from 1 to 20 pmp. In 2004, the mean rate of effective donors in Latin America was 5.4 pmp. The family refusal rate for the donation of organs varied from 28% in Uruguay to 70% in Peru. In some countries, such as Puerto Rico, Uruguay, and Cuba, it was more than 15 pmp, whereas in others countries deceased donors were practically not used. The number of patients on the waiting list for solid organ transplants in 12 Latin American countries is 55,000. Although the donation rate has increased by 100% during the last 10 years, it is lower than that in Europe (15 pmm/y) or the United States (20 pmp/y).
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Obtenção de Tecidos e Órgãos/estatística & dados numéricos , Morte Encefálica , Cadáver , Causas de Morte , Humanos , América Latina , Doadores Vivos/estatística & dados numéricos , Terapia de Substituição Renal/estatística & dados numéricos , Doadores de Tecidos/estatística & dados numéricos , Obtenção de Tecidos e Órgãos/economia , Obtenção de Tecidos e Órgãos/ética , Listas de EsperaAssuntos
Atitude , Transplante de Órgãos , Organizações sem Fins Lucrativos , Desenvolvimento de Programas , Obtenção de Tecidos e Órgãos/organização & administração , Adolescente , Adulto , Idoso , Análise Custo-Benefício , Feminino , Educação em Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Transplante de Órgãos/economia , Objetivos Organizacionais , Obtenção de Tecidos e Órgãos/economia , VenezuelaRESUMO
Intrarenal manometry (IRM) using the Salaman fine-needle technique was routinely performed in 28 renal transplant patients in order to make the differential diagnosis of acute tubular necrosis, cyclosporin nephrotoxocity, and acute rejection. A total of 246 IRM determinations with simultaneous percutaneous renal biopsies were obtained in cases of acute renal failure following a renal transplant. Normal IRM values were 21.4 +/- 1.3 mm Hg. After collecting the clinical data, cyclosporin levels, ultrasound information, response to therapy, and renal biopsy results, we retrospectively obtained 49 IRM measurements in acute rejection, 9 in cyclosporin nephrotoxicity, and 26 in acute tubular necrosis. The values in acute rejection (41.3 +/- 9.5 mm Hg) were significantly different from the normally functioning kidneys, cyclosporin nephrotoxicity, or acute tubular necrosis. The values in cyclosporin nephrotoxicity were slightly elevated when compared to the normal or acute tubular necrosis determinations (p < 0.04) but were still significantly lower than the acute rejection. Our results suggest that IRM represents a useful technique in the approach to the acute renal dysfunction in renal transplant recipients.
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Transplante de Rim/efeitos adversos , Necrose Tubular Aguda/diagnóstico , Manometria/métodos , Ciclosporina/efeitos adversos , Ciclosporina/uso terapêutico , Diagnóstico Diferencial , Rejeição de Enxerto/diagnóstico , Rejeição de Enxerto/etiologia , Humanos , Rim/efeitos dos fármacos , Testes de Função Renal , Necrose Tubular Aguda/etiologia , Manometria/instrumentação , Agulhas , Sensibilidade e EspecificidadeAssuntos
Transplante de Rim/estatística & dados numéricos , Sistema de Registros , Obtenção de Tecidos e Órgãos/estatística & dados numéricos , Cadáver , Causas de Morte , Humanos , Hipertensão , Transplante de Rim/mortalidade , América Latina , Nefrologia , Estudos Retrospectivos , Sociedades Médicas , Doadores de Tecidos , Obtenção de Tecidos e Órgãos/organização & administração , Listas de EsperaRESUMO
BACKGROUND: The Latin American Registry of Dialysis and Transplantation was created in October 1991 and comprises the National Societies of Nephrology from 21 countries with a total population of 468.56 million inhabitants. METHODS: This report includes data from 21,181 patients from Argentina, Brazil, Chile, El Salvador, Panama, Paraguay, Peru, Puerto Rico, Uruguay, and Venezuela who were receiving chronic dialysis treatment during 1993. Data was collected by individual patient questionnaires except from Chile and Brazil where the data was obtained from a local centre questionnaire. RESULTS: The prevalence rate averaged 131.1 per million population. The mean age of the 8972 incident patients was 50.5 years, with 58.2% males. The more frequent causes of renal failure were glomerulopathies (22.6%), vascular nephropathy (20.9%) and diabetes (16.9%). Haemodialysis was the most used treatment (88.3%). Gross mortality was 21.1% and the more frequent causes of death were cardiac complications and infections. The analysis of mortality risk factors using a logistic regression model showed that diabetics patients older than 65 years had the highest probability of death (43.0%) and patients with glomerulonephritis, younger than 65 years had the lowest (8.0%). The adjusted mortality rate was 241 deaths/1000 patient-years at risk when the USRDS 1987-1989 white mortality rate by age groups and primary diseases was used as standard. CONCLUSION: In spite of the economic difficulties, very important efforts have been made to treat ESRD patients and gross mortality statistics in some countries are similar to those reported by other regional registries.
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Transplante de Rim , Sistema de Registros , Terapia de Substituição Renal , Adolescente , Adulto , Distribuição por Idade , Idoso , Humanos , Nefropatias/epidemiologia , Nefropatias/mortalidade , Nefropatias/terapia , América Latina , Pessoa de Meia-Idade , Mortalidade , Prevalência , Fatores de RiscoRESUMO
Limited organ supply is currently the major obstacle to the transplantation programs around the world. As an alternative to increase the organ donation rate, we undertook a preliminary transplant coordinator program study, during a 6 month period, in five public hospitals, as part of the National Transplant Program of the Centro Nacional de Diálisis y Trasplante. The primary objective of the Transplant Coordinator Program was donor detection and organ procurement, along with education of the community. Forty five predonors were detected, with an average age of 25.8 +/- 1.6 years, of these, 36 were men (80%). None of them was a voluntary donor. The most frequent diagnoses were cranial trauma in 57.8% and stroke in 22.2% Forty two percent (42.3%) of the predonors were detected in the emergency room, 33.3% in intensive care units and 24.4% in the surgery recovery room. The conversion rate of predonors to donors were 29%. The main causes for not conversion of predonors into donors were: family refusal 44%, sepsis 13%, cardiac arrest 13%, and reduced renal function 6%. In conclusion, the Transplant Coordinator Program allows to increase the predonor detection and gives good information for adequate management of donor and public educational campaign about the subject.
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Transplante de Rim/estatística & dados numéricos , Obtenção de Tecidos e Órgãos/organização & administração , Adulto , Feminino , Administração Hospitalar , Humanos , Relações Interinstitucionais , Masculino , Projetos Piloto , Avaliação de Programas e Projetos de Saúde , Estudos Prospectivos , Doadores de Tecidos/estatística & dados numéricos , Obtenção de Tecidos e Órgãos/estatística & dados numéricos , Venezuela , Recursos HumanosRESUMO
In an open clinical trial we assessed the tolerance and safety of the 1:1 conversion of traditional cyclosporine A (CyA) to a new cyclosporine formulation based on a microemulsion technology (CyN) in 18 patients with stable renal allografts. 56% patients were female. Median patient age was 40.9 +/- 3.2 years (range 18 to 65). Renal transplantation was performed in 24.1 +/- 4.6 months (range 6 to 67 months), prior to the beginning of the study, and 67% of the transplants were from cadaveric donor. The most frequent underlying renal disease was glomerulonephritis (44.4%). None of the patients entering the study were withdrawn prematurely. After 2 weeks of observation for graft function stability, the study was divided in two phases: I: during 4 weeks the patients received CyA traditional at fixed doses (Mean dose administered 3.056 +/- 0.25 mg/Kg/d) and II: during the consecutive 6 weeks with conversion to CyN, with doses adjustment as required (Mean dose 2.887 +/- 0.21 mg/Kg/d). Clinical events, adverse reactions and laboratory parameters were evaluated. Levels of 100-200 ng/ml measured by monoclonal specific fluorescence polarization immunoassay were considered appropriate. There were no significant changes in physical examination and laboratory parameters between phases. The incidence of adverse reactions reported in phase I was only gingival hypertrophy (5%) which persisted in phase II, qualified as probably related to the cyclosporine, and in phase II tremor in 17%, qualified as definitively related. Both drugs were well tolerated and there was no report of acute rejection during the study. We conclude that the tolerance and safety of the 1:1 conversion of CyA to CyN were confirmed by our results, and considering the improved pharmacokinetic properties of the second, the microemulsion presentation will be used preferentially as immunosuppressive drug in the treatment of stable kidney transplant patients.
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Ciclosporina/administração & dosagem , Rejeição de Enxerto/prevenção & controle , Imunossupressores/administração & dosagem , Transplante de Rim/imunologia , Adolescente , Adulto , Idoso , Ciclosporina/efeitos adversos , Emulsões , Feminino , Hipertrofia Gengival/induzido quimicamente , Humanos , Imunossupressores/efeitos adversos , Masculino , Pessoa de Meia-IdadeRESUMO
We studied patients undergoing hemodialysis awaiting renal transplantation who had routine endoscopy as preoperative evaluation. Medical histories of 71 patients transplanted between 1982-1989 were reviewed retrospectively in order to determine the results of the upper gastrointestinal lesions. At the time of the endoscopy the predictive variables studied were: age, sex, BUN, creatinine, hemoglobin, hematocrit, calcium and time on hemodialysis. The patients were divided in two groups: those with lesions and a control group without lesions. The comparison between the two groups was done using unpaired t-test for continual variables, X2 for dichotomous variables and p < 0.05 was considered as statistically significant. Thirty two patients (45%) had lesions in the upper gastrointestinal tract, in the esophagus: 17%, stomach 30% and duodenum: 23%. Age was the only predictive variables statistically significant for gastric lesions. We conclude that gastrointestinal lesions are frequent in patients with end stage renal failure. The gastric lesions were the most frequent and appeared in older patients. We recommend endoscopic studies in all end stage renal failure patients as part of the pre transplant evaluation. We also suggest endoscopy as follow up after transplantation.
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Úlcera Duodenal/diagnóstico , Hiperemia/diagnóstico , Falência Renal Crônica/complicações , Púrpura/diagnóstico , Úlcera Gástrica/diagnóstico , Adolescente , Adulto , Fatores Etários , Estudos de Casos e Controles , Úlcera Duodenal/etiologia , Endoscopia Gastrointestinal , Feminino , Humanos , Hiperemia/etiologia , Masculino , Pessoa de Meia-Idade , Púrpura/etiologia , Diálise Renal , Estudos Retrospectivos , Úlcera Gástrica/etiologiaRESUMO
The number of cadaveric kidneys available for transplantation has become insufficient around the world. Despite concerted efforts, we have been unsuccessful in greatly improve the supply of organ donors, and consequently the number of end stage renal failure patients awaiting for kidney transplantation continues to increase. The primary objective of this paper is to quantify the need and supply of kidneys for transplant in Venezuela. An overview of the current level of kidney transplant activity in Venezuela is presented, observing that the activity with cadaveric donors had been predominant since 1983, although not to an optimal level. The annual activity in kidney transplant between 1989-1991 remained stable in 6 transplants/million people, but went sharply down to 4.6 in 1992. An estimate of the current need is around 10 donors/million people. This is in contrast with an effective donation rate of only 2.01 and 1.92 donors/million achieved in 1990 and 1991 respectively. The most frequent cause for no donation was the lack of familiar consent. Based on an analysis of the factors involved in the shortage of donor supply in Venezuela, we present some recommendations to increase the availability of cadaveric organ donors in the country. These measures include an improvement of education and legal regulation in the field of organ donation and transplantation, and following the Spanish model, the creation of a program of hospital transplant coordinators that can detect and evaluate potential organ donors as well as coordinate the logistical aspects of transplantation.
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Transplante de Rim/estatística & dados numéricos , Doadores de Tecidos/provisão & distribuição , Humanos , Estudos Retrospectivos , Venezuela , Listas de EsperaRESUMO
These studies examine the regulation of adenylate cyclase in renal cortical membranes from phosphate-deprived and phosphate-deprived acidotic dogs. Enzyme stimulation by parathyroid hormone (PTH) was decreased in phosphate deprivation [Vmax 1,578 +/- 169 vs. 2,581 +/- 219 pmol adenosine 3',5'-cyclic monophosphate (cAMP).mg protein-1 x 30 min-1 in controls, P less than 0.01]. Metabolic acidosis further decreased PTH-stimulated activity. Membranes from phosphate-deprived dogs showed a decrease in Gs alpha-content by cholera toxin-dependent ADP-ribosylation (174 +/- 18 arbitrary units vs. 266.4 +/- 13.6 in controls, P less than 0.01). Metabolic acidosis further decreased Gs alpha-content, P less than 0.01. Gi content by pertussis-dependent ADP-ribosylation was also lower in phosphate-deprived and phosphate-deprived acidotic animals. Gs function was examined by its property to protect the catalytic unit from inactivation by N-ethylmaleimide when preincubated with GTP gamma S. In controls, protection of inactivation was 80% of the maximal activity, whereas in phosphate deprivation protection was less than 50%. In conclusion, metabolic acidosis enhances adenylate cyclase resistance to PTH in phosphate deprivation. These alterations are associated with a decrease in the content and function of Gs alpha, suggesting a role of Gs in the renal adaptation to phosphate depletion and acidosis.
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Acidose/metabolismo , Adenilil Ciclases/metabolismo , Proteínas de Ligação ao GTP/fisiologia , Rim/enzimologia , Hormônio Paratireóideo/farmacologia , Fósforo/deficiência , Acidose/induzido quimicamente , Adenosina Difosfato Ribose/metabolismo , Toxina Adenilato Ciclase , Cloreto de Amônio , Animais , Toxina da Cólera/farmacologia , Colforsina/farmacologia , Cães , Etilmaleimida/farmacologia , Nucleotídeos de Guanina/metabolismo , Nucleotídeos de Guanina/farmacologia , Guanosina 5'-O-(3-Tiotrifosfato) , Guanosina Trifosfato/análogos & derivados , Guanosina Trifosfato/farmacologia , Magnésio/farmacologia , Manganês/farmacologia , Proteínas de Membrana/metabolismo , Toxina Pertussis , Fluoreto de Sódio/farmacologia , Tionucleotídeos/farmacologia , Fatores de Virulência de Bordetella/farmacologiaRESUMO
The loss of renal mass is associated with functional adaptations in the remaining nephrons to maintain homeostasis. Although parathyroid hormone (PTH) is important in the adaptations to phosphate, the mechanisms are not completely defined. In the present studies we examined the response of the adenylate cyclase system to PTH in renal cortical membranes of rat kidneys ten days after unilateral nephrectomy. The kidneys obtained at the time of the initial nephrectomy were used as controls. Unilateral nephrectomy resulted in contralateral compensatory renal growth, as demonstrated by a 24 +/- 4.7% (P less than 0.01) increase in weight in the remaining kidney. Glomerular filtration rate (GFR) after unilateral nephrectomy was 62% of the control, while basal fractional phosphate excretion was higher in rats with unilateral nephrectomy (7.7 +/- 2.1% vs. 2.9 +/- 0.8%, P less than 0.05). PTH infusion resulted in a similar increase of fractional phosphate excretion and urinary cAMP in both groups. In the absence of added guanine nucleotides, PTH-dependent adenylate cyclase activity in cortical membranes from kidneys with compensatory growth was decreased as compared to controls (Vmax 807.5 +/- 62.7 pmol cAMP/mg protein/30 min vs. 1,384.8 +/- 116.1, respectively, P less than 0.01). The apparent affinity for PTH stimulation of adenylate cyclase (Kact) was unchanged. Magnesium-dependent adenylate cyclase activity was also decreased in the membranes from kidneys with compensatory growth. However, the kinetics of adenylate cyclase for the substrates ATP-Mg or ATP-Mn were similar.(ABSTRACT TRUNCATED AT 250 WORDS)