RESUMO
Thymomas are tumors characterized by a remarkable morphological heterogeneity and variable clinical behavior. This tumor has unique clinical associations, most notably with hematological abnormalities and myasthenia gravis. According with the Müller-Hermelink criteria, there are significant differences between the histological types of thymomas and the association with myasthenia gravis. Among the different histological types, medullary thymoma is the least frequent variant associated with this autoimmune disease. In this report we describe a case of medullary thymoma presenting in a 71-year- old woman with a myasthenic syndrome.
Assuntos
Miastenia Gravis/complicações , Timoma/complicações , Neoplasias do Timo/complicações , Idoso , Feminino , Humanos , Miastenia Gravis/patologia , Timoma/patologia , Neoplasias do Timo/patologiaRESUMO
El carcinoma papilar dimórfico (CPD) de la mama, caracterizado por una doble población de células epiteliales malignas, es una entidad descrita en 1994 que puede ser causa de falsos negativos en lesiones papilares de la mama. Presentamos el caso de una mujer de 77 años con el diagnóstico de CPD infiltrante de la mama, entidad definida morfológicamente por una delgada banda de células epiteliales columnares sobre la superficie de anchas papilas anastomosadas, que aparecen rellenas de una segunda población de células cuboidales con abundante citoplasma claro o débilmente eosinófilo. Los núcleos de ambas células son idénticos. (AU)
Assuntos
Idoso , Feminino , Humanos , Carcinoma Papilar/cirurgia , Neoplasias da Mama/cirurgia , Carcinoma Papilar/diagnóstico , Células Epiteliais , Mastectomia/métodos , Excisão de Linfonodo/métodos , Imuno-Histoquímica/métodos , Neoplasias da Mama/diagnósticoRESUMO
AIMS: To evaluate the prevalence of pseudoangiomatous hyperplasia of mammary stroma in gynaecomastia and its immunohistochemical profile in this setting. METHODS: Eighty eight cases of gynaecomastia recovered from the files of the department of pathology, Botucatu School of Medicine from 1976 to 1996 were studied. In the cases associated with pseudoangiomatous hyperplasia of mammary stroma, immunoreactivity for cytokeratins (CAM 5.2), vimentin, CD34, factor VIII related antigen, and the oestrogen and progesterone receptors were studied. RESULTS: Pseudoangiomatous hyperplasia of mammary stroma was found in 21 of 88 cases of gynaecomastia (23.8%). In all cases, the cells lining the spaces were positive for vimentin, whereas CAM 5.2 and factor VIII related antigen were consistently negative. Nineteen of the 21 cases showed immunoreactivity for CD34. Ductal epithelial cells were positive for both the oestrogen receptor and the progesterone receptor, whereas stromal cells were negative. CONCLUSIONS: Pseudoangiomatous hyperplasia of mammary stroma was present in approximately one quarter of the cases of gynaecomastia. This immunohistochemical study confirms the mesenchymal origin of the stromal cells that line the pseudovascular spaces, as has been found in female cases of pseudoangiomatous hyperplasia of mammary stroma.
Assuntos
Angiomatose/patologia , Mama/patologia , Ginecomastia/patologia , Adolescente , Adulto , Angiomatose/etiologia , Angiomatose/metabolismo , Antígenos CD34/metabolismo , Mama/metabolismo , Criança , Ginecomastia/complicações , Humanos , Hiperplasia/etiologia , Hiperplasia/metabolismo , Hiperplasia/patologia , Imuno-Histoquímica , Masculino , Vimentina/metabolismoRESUMO
Keratoacanthoma is a rapidly growing skin neoplasia that may stabilize or regress spontaneously. We describe here a case of conjunctival keratoacanthoma and comment about the clinical signs and symptoms and pathological findings.
