1.
Org Lett
; 19(8): 1966-1969, 2017 04 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28375015
RESUMO
A Pd-catalyzed ring-opening of ß-lactones with various types of amines (primary, secondary, and aryl) to provide ß-hydroxy amides with excellent selectivity toward acyl C-O bond cleavage is reported. The utility of this protocol is demonstrated in an asymmetric kinetic resolution providing enantioenriched α-methylene-ß-lactones.