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J Neuroimmunol ; 203(1): 50-7, 2008 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-18657867

RESUMO

Myeloid-derived immune cells, including microglia, macrophages and monocytes, have been previously implicated in neurodegeneration. We investigated the role of infiltrating peripheral blood mononuclear cells (PBMC) in neuroinflammation and neurodegeneration in the HexB-/- mouse model of Sandhoff disease. Ablation of the chemokine receptor CCR2 in the HexB-/- mouse resulted in significant inhibition of PBMC infiltration into the brain, decrease in TNFalpha and MHC-II mRNA abundance and retardation in clinical disease development. There was no change in the level of GM2 storage and pro-apoptotic activity or astrocyte activation in HexB-/-; Ccr2-/- double knockout mice, which eventually succumbed secondary to GM2 gangliosidosis.


Assuntos
Encefalite/imunologia , Hexosaminidase B/imunologia , Leucócitos Mononucleares/imunologia , Degeneração Neural/imunologia , Doença de Sandhoff/imunologia , Animais , Apoptose/imunologia , Modelos Animais de Doenças , Encefalite/metabolismo , Encefalite/patologia , Feminino , Gangliosídeo G(M2)/metabolismo , Hexosaminidase B/genética , Leucócitos Mononucleares/patologia , Masculino , Camundongos , Camundongos Knockout , Microglia/imunologia , Microglia/patologia , Degeneração Neural/metabolismo , Degeneração Neural/patologia , Receptores CCR2/genética , Receptores CCR2/imunologia , Doença de Sandhoff/metabolismo , Doença de Sandhoff/patologia
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