New lesions on the knees with palmoplantar keratoderma.

A 40-year-old Latin American woman presented for evaluation with a 5-week history of redness, thickened skin, and itching of the knees, as well as persistent redness and thickened skin of the palms and soles consistent with Papillon-Lefèvre syndrome (PLS). The article discusses the clinical presentation and treatment of PLS.