1.
Bioorg Med Chem
; 25(7): 2218-2225, 2017 04 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28279558
RESUMO
Functionalised tetrahydropyran scaffolds were prepared using a tethered enol-ether Prins cyclisation and elaborated to show their potential use in library synthesis. The key 4-hydroxytetrahydropyran scaffold could be readily manipulated to the 4-azidotetrahydropyran that could be elaborated via copper catalysed azide-alkyne cycloaddition or by reduction to the amine, to provide sp3-rich scaffolds useful for drug discovery.