[Computer simulation of ESR signals of liver paramagnetic centers]. / Modelirovanie s pomoshch'iu EVM signalov EPR paramagnitnykh tsentrov pecheni.

Changes of paramagnetic centres concentration characterized by g-factors values of 1.94, 2.2, and 2.03 in the rat liver were studied by ESR method under acute intoxication by diethylnitrosamine (DENA) and at preliminary threefold treatment of animals with butylhydroxytoluene (BHT). A protective effect of BHT can be explained by its stabilizing action of the membrane structures. A comparison has been carried out with a similar study of paramagnetic centres in the experiment of chronic intoxication by DENA. A simulation was performed of the liver tissue ESR spectra by means of special computer program. The parameters of simulated ESR spectra of the liver tissue with due regard for ESR signal g 2.03 corresponded to the parameters of the experimental spectra. Confirmations were obtained for the nature and number of paramagnetic centres in the liver tissue.

[Computer modeling of ESR spectra of the plasma in patients with Down's syndrome]. / Modelirovanie s pomoshch'iu EVM spektrov EPR plazmy krovi u bol'nykh s sindromom Dauna.

ESR technique at 77 degrees K was used for studying the blood plasma ESR signals of patients with Down syndrome and of healthy people. It was observed that the first exhibited a tendency towards a decrease of ESR signal with g = 4.3 and increase of the ratio of ceruplasmin (g = 2.05) and transferrin (g = 4.3) ESR signal amplitude. A computer simulation has been carried out by means of special mathematical program of experimental ESR spectra of the blood plasma.

[The effect of highly-dispersed zinc powder on the functional state of blood components and rat liver mitochondria]. / Vliianie vysokodispersnogo poroshka tsinka na funktsional'noe sostoianie komponentov krovi i mitokhondrii pecheni krys.

The functional state of blood components and liver mitochondria have been investigated by means of ESR method and atomic adsorption spectroscopy. The experimental data indicated that injection of highly dispersed Zn-powder in the concentration of 5 mg/kg of weight did not result in disturbance of mitochondria bioenergetic functions, although the functional state of blood components and the level of metal ions in it were changed.

[Free radicals and oxidative phosphorylation in chemical carcinogenesis]. / Svobodnye radikaly i okislitel'noe fosforilirovanie pri khimicheskom kantserogeneze.

Rat liver mitochondria were investigated at DEN induced chemical cancerogenesis. The intensity of ESR signal (g = 2.00) at 77 K was measured in parallel with respiratory control indicating the relationship between oxidation and ATP synthesis levels. Correlation between these values was obtained. Consequently the change of ESR signal (g = 2.00) intensity at cancerogenesis may be to a great extent associated with the state of the coupling system in mitochondria.

[Electron paramagnetic resonance spectra with g=2.03 of the animal liver tissue treated with butylhydroxytoluene and diethylnitrosamine]. / Spektry élektronnogo paramagnitnogo rezonansa s g=2,03 tkanei pecheni zhivotnykh pri deistvii butilgidroksitoluola i diétilnitrozamina.

ESR spectra g=2.03 intensities of rat liver tissues were studied under the action of cancer agent either diethylnitrosamine (DEN) with butylhydroxytoluene (BHT) injected before DEN or without BHT at 77 K. Combined influence of DEN and BHT upon the intensity change of ESR spectra with g=2.03 at animal disease is explained by modified action of DEN metabolism.