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Bioorg Med Chem ; 23(3): 632-47, 2015 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-25549898

RESUMO

The prevalence of drug resistance in both clinical and community settings as a consequence of alterations of biosynthetic pathways, enzymes or cell wall architecture is a persistent threat to human health. We have designed, synthesized, and tested a novel class of non-transpeptidase, ß-lactamase resistant monocyclic ß-lactams that carry an arylthio group at C4. These thioethers exhibit inhibitory and cidal activity against serine ß-lactamase producing Mycobacterium tuberculosis wild type strain (Mtb) and multiple (n=8) ß-lactamase producing Moraxella catarrhalis clinical isolates.


Assuntos
Antibacterianos/farmacologia , Moraxella catarrhalis/efeitos dos fármacos , Mycobacterium tuberculosis/efeitos dos fármacos , beta-Lactamas/farmacologia , Antibacterianos/química , Testes de Sensibilidade Microbiana , Moraxella catarrhalis/enzimologia , Mycobacterium tuberculosis/enzimologia , beta-Lactamas/química , beta-Lactamas/metabolismo
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