RESUMO
In this study we evaluated the relationship between polyglucosan bodies and peripheral nerve lesions. The biopsied sural nerve from a patient with late-onset chronic sensori-motor neuropathy showed many intra-axonal polyglucosan bodies and segmental demyelination/remyelination. The formation of Schwann cell hyperplasia around the demyelinated axons was found at the sites of polyglucosan bodies. These findings suggest that demyelinating neuropathy is a part of the spectrum of the diseases characterized by the accumulation of polyglucosan bodies within cellular compartments.
Assuntos
Axônios/ultraestrutura , Doenças Desmielinizantes/patologia , Glucanos/metabolismo , Corpos de Inclusão/ultraestrutura , Idoso , Doença Crônica , Doenças Desmielinizantes/metabolismo , Humanos , Masculino , Fibras Nervosas Mielinizadas/ultraestrutura , Células de Schwann/ultraestrutura , Nervo Sural/patologiaAssuntos
Hanseníase/complicações , Neuralgia/tratamento farmacológico , Carbamazepina/administração & dosagem , Quimioterapia Combinada , Eritema Nodoso/complicações , Eritema Nodoso/patologia , Feminino , Glucocorticoides/administração & dosagem , Humanos , Hanseníase/patologia , Masculino , Neuralgia/etiologia , Vitamina B 12/administração & dosagem , Vitamina B 12/análogos & derivadosRESUMO
Four middle-aged male Chinese with polyneuropathy, skin hyperpigmentation, oedema, hepatosplenomegaly, ascites, gynaecomastia and white nails are described. In Japan and United States this syndrome has been associated with plasma cell dyscrasia. However, neither M-protein nor skeletal lesions were demonstrated in these four patients.