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Objective To investigate the effects of butylphthalide injection on cerebral blood flow (CBF) perfusion and cognitive function in patients with acute cerebral infarction accompanied by cognitive disorder.Methods From September 2016 to September 2017,80 patients with acute cerebral infarction and cognitive impairment were admitted to the Department of Neurology,Yan'an Hospital of Kunming Medical University.They were assigned to an observation group (n=40) and a control group (n=40).The control group received conventional treatment while the observation group received butylphthalide injection in addition to conventional treatment.The treatment lasted for 14 days for both groups.Before and after treatment,dynamic susceptibility contrast-enhanced perfusion-weighted imaging (DSC-PWI) was used to measure the CBF parameters in the cerebral ischemic region,and Montreal Cognitive Assessment (MoCA) was used to evaluate the changes in cognitive function.Results After treatment,rCBF and rCBV increased significantly and rMTT and rTTP decreased significantly in the observation group (P＜0.05).After treatment,there were significant improvements in MoCA subscores and total score in the observation group (P＜0.05).In the observation group,the post-treatment increases in rCBV and rCBF were positively correlated with increased MoCA total score (r=0.474,P=0.013;r=0.282,P=0.027),and the post-treatment decreases in rMTT and rTTP were negatively correlated with increased MoCA total score (r=-0.294,P=0.021;r=0.382,P=0.019).Conclusion Butylphthalide injection can safely improve CBF perfusion in the focal region and cognitive function in patients with acute cerebral infarction,with no obvious adverse reactions.
RESUMO
Objective To investigate whether panax notoginseng saponins(三七总皂苷,PNS) can inhibit the activity of lung nuclear factor-?B(NF-?B) and ameliorate the lung pathologic injury in rats with acute necrotizing pancreatitis(ANP).Methods Thirty Sprague-Dawley(SD) rats were randomly divided into three groups: sham operation group(group sham),ANP group(group ANP),PNS preconditioning group(group PNS).There were 10 rats in each group.Rat ANP model was induced by retrograde injection of 5% sodium taurocholate to pancreatic duct(1 ml/kg).The rats in the PNS preconditioning group were given by intraperitoneal injection of 50 g/L PNS(1 ml/kg) one hour before model establishment,and those in the other two groups were given 0.9% physiological saline(1 ml/kg) one hour before the operation.Put the rat in each group to death at 6 hours after the respective management was made,and the pulmonary tissues were taken to detect the activity of NF?B by immunohistochemistry and the wet/dry weight ratio of the lung tissue was measured.Results At 6 hours after the model was established in the ANP group,the NF-?B positive cell number(70%-100% positive cells,7 vs.0) and the positive unit((72.52?7.63)PU vs.(33.09?4.75)PU) in the lung tissue were remarkably increased in comparisons with those in the sham group(both P
