[Heart rupture in the acute period of myocardial infarction: prognostication and ways of prevention]. / Razryv serdtsa v ostrom periode infarkta miokarda, prognozirovanie i puti profilaktiki.

Clinical, instrumental, and biochemical examinations were carried out in 587 patients with transmural myocardial infarctions (381 patients with the first infarction and 206 ones with the repeated disease). Heart ruptures occurred in 5.7% of cases. Clinical forms and risk factors of heart rupture are described. Another group consisted of 815 patients with the first transmural infarction; in 44 patients at a high risk of heart ruptures preventive therapy with pantripin and contrykal was carried out. The incidence of heart ruptures was reduced twofold in this group as against the controls. Heart rupture risk factors in patients with myocardial infarction are described. The syndrome of excessive resorption in the pre-rupture period of myocardial infarction was singled out, manifesting by increased activities of lactate dehydrogenase, lysosomal enzymes, and elevated level of cardiac antigen. Lysosomal enzyme levels were measured in the myocardium in heart ruptures. The authors have defined the notion of 'mechanical incompetence' in myocardial infarction, consisting in inability of the involved myocardium to resist the intraventricular blood pressure. The program of heart rupture prevention in myocardial infarction is presented.

[The prognosis and prevention of cardiac muscle ruptures in myocardial infarct]. / Pronozirovanie i profilaktika razryvov serdechnoi myshtsy pri infarkte miokarda.

This article is based on the examination of 850 patients with acute transmural myocardial infarction, including 48 fatal cases in the result of external cardiac rupture. Immunological and biochemical indices of all patients have shown a high rate of necrotic processes in cardiac muscle in cases of heart rupture. The authors disclose the risk factors of cardiorrhexis and give recommendations for its prophylaxis.

[Change in the activity of creatine kinase and its MB isoenzyme as affected by partial and complete occlusion of the coronary artery in rats]. / Izmenenie aktivnosti kreatinkinazy i ee izofermenta MB pri chastichnoi i pol'noi okkliuzii koronarnoi arterii u krys.

A model of different degree left coronary artery (LCA) occlusion in rats has been developed. The activity of creatine kinase and its cardiospecific MB isoenzyme was determined both in the cardiac muscle and blood plasma of 62 animals at different time after complete or partial LCA occlusion. A direct dependence of the decrease in the enzyme activity in the heart and hyperfermentemia on the degree of LCA occlusion has been established. It is concluded that the model of LCA occlusion in rats could be useful for the study of different forms and stages of myocardial ischemia.

[Effect of L-DOPA on cyclic adenosine-3',5'-monophosphate in neurogenically damaged cardiac muscle]. / Vliianie L-DOFA na soderzhanie tsiklicheskogo adenozin-3',5'-monofosfata pri neirogennom povrezhdenii serdechnoi myshtsy.

During electric stimulation of the aortal reflexogenic zone in rabbits, administration of L-DOPA prevented the reduction of the level of cyclic adenosine-3',5'-monophosphate (cAMP) in the cardiac muscle and blood plasma. This is likely to be related to L-DOPA ability to participate in the biosynthesis of endogenous catecholamines, and thus to stimulate the synthesis of cAMP.