RESUMO
OBJECTIVE: To assess efficacy and safety of two dilutions of botulinum neurotoxin type A NT 201 (Xeomin®) in patients with upper limb spasticity of diverse etiology. METHODS: Changes in functional disability and muscle tone from baseline to week 4 after NT 201 treatment. RESULTS: One hundred ninety-two patients with stroke, brain injury, multiple sclerosis, or cerebral palsy were randomized to either 50 or 20 U/ml NT 201 dilutions. The maximum total NT 201 dose was 495 units. Four weeks post-injection, a ≥ 1-point reduction was observed on the Disability Assessment Scale in 57.1%, and on the Ashworth scale in ≥ 62.2% of patients. The 20 U/ml NT 201 dilution was non-inferior to the 50 U/ml NT 201 dilution. Global improvement was rated high by patients (80.2%) and investigators (89.0%). CONCLUSIONS: NT 201 improved functional disability and muscle tone and was well tolerated in patients with upper limb spasticity of diverse etiology in both dilutions.
Assuntos
Toxinas Botulínicas Tipo A/uso terapêutico , Espasticidade Muscular/terapia , Extremidade Superior/fisiopatologia , Adulto , Idoso , Toxinas Botulínicas Tipo A/efeitos adversos , Lesões Encefálicas/complicações , Lesões Encefálicas/fisiopatologia , Paralisia Cerebral/complicações , Paralisia Cerebral/fisiopatologia , Feminino , Hematoma/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Esclerose Múltipla/complicações , Esclerose Múltipla/fisiopatologia , Espasticidade Muscular/etiologia , Espasticidade Muscular/fisiopatologia , Debilidade Muscular/etiologia , Estudos Prospectivos , Acidente Vascular Cerebral/complicações , Acidente Vascular Cerebral/fisiopatologia , Resultado do TratamentoRESUMO
A 7-month-old previously healthy female infant was found dead in her crib by her mother shortly after having been laid down to sleep following the noontime feeding. Because the child did not suffer from an acute illness and no other evidence pointed to a cause of death, it was initially assumed by the police that she had died of sudden infant death syndrome. At autopsy, however, the cause of death was determined to be cardiac arrhythmia secondary to fibroma of the heart.
Assuntos
Fibroma/mortalidade , Neoplasias Cardíacas/mortalidade , Morte Súbita do Lactente , Causas de Morte , Feminino , Fibroma/patologia , Medicina Legal , Neoplasias Cardíacas/patologia , Humanos , LactenteRESUMO
The case history presented reports on three 30- to 40-years-old men, who were found dead in a party like situation in the living room. The toxicological investigation proved alcohol and THC as well as therapeutic Flunitrazepam- and Pentobarbital levels and toxic 7- Amino-Flunitrazepam concentrations. The background of this surprising scene led up to the conclusion of an accidental death caused by a mixed intoxication.
