High definition 4K-three-dimensional exoscope for removal of a C1-C2 meningioma: Technical case report / Meningioma espinal C1-C2 extirpado con un exoscopio tridimensional y resolución 4K: reporte técnico de caso clínico

In recent years, the exoscope has been proposed as an alternative to the microscope when a magnified view of the surgical field is required in spinal surgery. We present a case of a 52-year-old patient in which a meningioma in the upper cervical spine (C1-C2) was removed using a 4K-three-dimensional (3D) exoscope. The advantages of surgical removal of an intradural spinal tumor using an exoscope are illustrated, focusing mainly on vision quality and ergonomics. In addition, some technical details regarding the operating room setup are provided. Based on this experience, a 4K-3D exoscope can be useful for spinal tumor surgery when high magnification of anatomical details is required, allowing the surgeon to operate in a comfortable position throughout the surgical procedure. (AU)

En los últimos años, el exoscopio se ha propuesto como alternativa al microscopio cuando se requiere una visión ampliada del campo quirúrgico, incluso en la cirugía de la columna vertebral. Presentamos un caso clínico de un paciente de 52 años en el que se extirpó un meningioma en la columna cervical superior (C1-C2) utilizando un exoscopio tridimensional con resolución 4K (4K-3D). Se ilustran las ventajas de la extirpación quirúrgica de un tumor espinal intradural con exoscopio, centrándose principalmente en la calidad de la visión y en la ergonomía. Además, se ofrecen algunos detalles técnicos sobre la configuración del quirófano. Nuestra experiencia sugiere que un exoscopio 4K-3D puede ser muy útil para la cirugía de tumores espinales cuando se requiere una gran ampliación de los detalles anatómicos, permitiendo también al cirujano operar en una posición cómoda durante todo el procedimiento quirúrgico. (AU)

High definition 4K-three-dimensional exoscope for removal of a C1-C2 meningioma: Technical case report.

In recent years, the exoscope has been proposed as an alternative to the microscope when a magnified view of the surgical field is required in spinal surgery. We present a case of a 52-year-old patient in which a meningioma in the upper cervical spine (C1-C2) was removed using a 4K-three-dimensional (3D) exoscope. The advantages of surgical removal of an intradural spinal tumor using an exoscope are illustrated, focusing mainly on vision quality and ergonomics. In addition, some technical details regarding the operating room setup are provided. Based on this experience, a 4K-3D exoscope can be useful for spinal tumor surgery when high magnification of anatomical details is required, allowing the surgeon to operate in a comfortable position throughout the surgical procedure.

Real-time navigation in spinal surgery: what has changed in surgical practice?

BACKGROUND: The authors have carried out a retrospective study to assess the advantages of real-time spinal navigation with 3D-fluoro images (O-arm® and StealthStation® navigation systems, Medtronic, Minneapolis, MN, USA) versus fluoroscopy in spinal surgery. The aim of the study is to ascertain whether this technology has affected surgical indications and clinical practice. METHODS: From January 2009 to December 2013, 421 patients underwent image-guided spinal surgery procedures in our department. They were divided into two main groups: group 1: operated on with C-arm fluoroscopic control; group 2: operated on with real-time navigation with 3D-fluoro images. All patients with vertebral osteosynthesis underwent a postoperative CT scan to check the final position of the screws. RESULTS: The screw misplacement proved to be 5.8% in group 1 and 1.5% in group 2. The odds ratio was 4.2 (95% confidence interval 2.3-7.5) with statistical significance (P<0.0001). The results clearly show an increased number of percutaneous procedures in group 2, as well as longer open osteosynthesis. CONCLUSIONS: Navigation with 3D-fluoro images reduces screw misplacement, facilitates osteosynthesis in the most difficult vertebral segments and allows broader use of percutaneous techniques, when indicated.

Management of nontraumatic intracranial hemorrhage.

The modern treatment of spontaneous intracranial hemorrhages requires a multidisciplinary approach including neurosurgery, interventional neuroredicology, vascular neurology and radiosurgery to determine the best management strategy.

Local intracerebral delivery of endogenous inhibitors by osmotic minipumps effectively suppresses glioma growth in vivo.

The systemic administration of endogenous inhibitors significantly reduced the growth of human glioma in vivo, but required the production of a large amount of biologically active protein. In this study we reduced the amount of protein needed and optimized the therapeutical response by delivering the endogenous inhibitors locally into the brain by osmotic minipumps. Human hemopexin fragment of MMP-2 or COOH-terminal fragment of platelet factor-4 were delivered locally and continuously into the brain of mice implanted intracranially with glioma cells, by osmotic minipumps connected to an intracranial catheter. Local delivery of human hemopexin fragment of MMP-2 and COOH-terminal fragment of platelet factor-4 significantly inhibited the growth of well-established malignant glioma in nude and BALB/C mice. When the inhibitors were given at the same concentration, the efficacy of the local delivery was much higher than that reached with the systemic administration, both when the inhibitor was administered daily or continuously by s.c. minipumps. Moreover, the local delivery reduced the amount of protein needed to reach a significant therapeutic response. Intracerebral delivery maintained a long-term control of glioma growth and inhibited glioma recurrence in a surgical resection model. Treatment showed no side effects. Histochemical analysis of tumors showed that the tumor growth inhibition was the result of a decrease in tumor vasculature and a change in tumor vessel morphology. Our data demonstrate that local intracerebral delivery of endogenous inhibitors effectively inhibits malignant glioma growth and reduces the amount of protein needed to reach a therapeutical response.