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J Trop Pediatr ; 50(6): 377-8, 2004 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-15537729

RESUMO

The last successfully treated case of congenital trypanosomiasis in Zambia was in October 1978, with detailed analysis of immunoglobulins, illustrating the waning of blood and serum levels of IgA, IgG, and IgM during treatment, up to 99 days after treatment. Twenty-five years later, we report on a case of congenital trypanosomiasis. The disease is now rare and can be missed or dismissed as retroviral disease, particularly in adults. The main unusual symptoms were the prolonged intermittent convulsions in an otherwise well infant. Management of the disease is now more interdisciplinary, resources for laboratory support are fewer, lumbar puncture is more relevant, and antitrypanosomal drugs are more difficult to obtain. The mother died within one week of hospitalization and the infant initially responded to three doses of suramin and 3 weeks of melsopropol. Convulsions ceased during the second round of melsopropol. Unfortunately, the infant died of nosocomial infection.


Assuntos
Transmissão Vertical de Doenças Infecciosas , Complicações Parasitárias na Gravidez/diagnóstico , Tripanossomíase/congênito , Tripanossomíase/diagnóstico , Adulto , Países em Desenvolvimento , Progressão da Doença , Evolução Fatal , Feminino , Humanos , Lactente , Gravidez , Medição de Risco , Índice de Gravidade de Doença , Tripanossomicidas/uso terapêutico , Tripanossomíase/terapia , Zâmbia
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