RESUMO
Patients with acute schistosomiasis were studied before and after oxamniquine treatment. They had been exposed to cercariae 5 to 9 weeks before, and presented compatible clinical manifestations, eosinophilia, and high levels of total IgE. Interferon-gamma (IFN-gamma) and interleukin-4 were measured by ELISA in whole blood samples under soluble egg antigen or soluble adult worm preparation stimulation. After treatment, the reduction of leukocytosis and eosinophilia were not significant, but total IgE levels decreased significantly, in contrast to IFN-gamma levels that were significantly increased. The oxamniquine treatment of acute schistosomiasis patients is followed by an improvement of a Th1 response in vitro. If this response has a protective aspect is unknown, and some investigations need to be realized.
Assuntos
Antígenos de Helmintos/imunologia , Interferon gama/biossíntese , Oxamniquine/uso terapêutico , Schistosoma mansoni/imunologia , Esquistossomose mansoni/tratamento farmacológico , Esquistossomicidas/uso terapêutico , Doença Aguda , Adolescente , Adulto , Animais , Anticorpos Anti-Helmínticos/sangue , Criança , Surtos de Doenças , Ensaio de Imunoadsorção Enzimática , Fezes/parasitologia , Feminino , Humanos , Imunoglobulina E/sangue , Interferon gama/imunologia , Masculino , Contagem de Ovos de Parasitas , Esquistossomose mansoni/sangue , Esquistossomose mansoni/imunologiaRESUMO
Patients with acute schistosomiasis were studied before and after oxamniquine treatment. They had been exposed to cercariae 5 to 9 weeks before, and presented compatible clinical manifestations, eosinophilia, and high levels of total IgE. Interferon-gamma (IFN-gamma) and interleukin-4 were measured by ELISA in whole blood samples under soluble egg antigen or soluble adult worm preparation stimulation. After treatment, the reduction of leukocytosis and eosinophilia were not significant, but total IgE levels decreased significantly, in contrast to IFN-gamma levels that were significantly increased. The oxamniquine treatment of acute schistosomiasis patients is followed by an improvement of a Th1 response in vitro. If this response has a protective aspect is unknown, and some investigations need to be realized.
