A review on inertial microfluidic fabrication methods.

In recent decades, there has been significant interest in inertial microfluidics due to its high throughput, ease of fabrication, and no need for external forces. The focusing efficiency of inertial microfluidic systems relies entirely on the geometrical features of microchannels because hydrodynamic forces (inertial lift forces and Dean drag forces) are the main driving forces in inertial microfluidic devices. In the past few years, novel microchannel structures have been propounded to improve particle manipulation efficiency. However, the fabrication of these unconventional structures has remained a serious challenge. Although researchers have pushed forward the frontiers of microfabrication technologies, the fabrication techniques employed for inertial microfluidics have not been discussed comprehensively. This review introduces the microfabrication approaches used for creating inertial microchannels, including photolithography, xurography, laser cutting, micromachining, microwire technique, etching, hot embossing, 3D printing, and injection molding. The advantages and disadvantages of these methods have also been discussed. Then, the techniques are reviewed regarding resolution, structures, cost, and materials. This review provides a thorough insight into the manufacturing methods of inertial microchannels, which could be helpful for future studies to improve the harvesting yield and resolution by choosing a proper fabrication technique.

Enhanced Piezoelectricity of PVDF-TrFE Nanofibers by Intercalating with Electrosprayed BaTiO3.

Over the past few decades, flexible piezoelectric devices have gained increasing interest due to their wide applications as wearable sensors and energy harvesters. Poly(vinylidene fluoride-trifluoroethylene) (PVDF-TrFE), as one of piezoelectric polymers, has caught considerable attention because of its high flexibility, high thermal stability, and biocompatibility. However, its relatively lower piezoelectricity limits its broader applications. Herein, we present a new approach to improving the piezoelectricity of PVDF-TrFE nanofibers by integrating barium titanate (BTO) nanoparticles. Instead of being directly dispersed into PVDF-TrFE nanofibers, the BTO nanoparticles were electrosprayed between the nanofiber layers to create a sandwich structure. The results showed that the sample with BTO sandwiched between PVDF-TrFE nanofibers showed a much higher piezoelectric output compared to the sample with BTO uniformly dispersed in the nanofibers, with a maximum of ∼ 457% enhancement. Simulation results suggested that the enhanced piezoelectricity is due to the larger strain induced in the BTO nanoparticles in the sandwich structure. Additionally, BTO might be better poled during electrospraying with higher field strength, which is also believed to contribute to enhanced piezoelectricity. The potential of the piezoelectric nanofiber mats as a sensor for measuring biting force and as a sensor array for pressure mapping was demonstrated.

Wearable Sensors for Remote Health Monitoring: Potential Applications for Early Diagnosis of Covid-19.

Wearable sensors are emerging as a new technology to detect physiological and biochemical markers for remote health monitoring. By measuring vital signs such as respiratory rate, body temperature, and blood oxygen level, wearable sensors offer tremendous potential for the noninvasive and early diagnosis of numerous diseases such as Covid-19. Over the past decade, significant progress has been made to develop wearable sensors with high sensitivity, accuracy, flexibility, and stretchability, bringing to reality a new paradigm of remote health monitoring. In this review paper, the latest advances in wearable sensor systems that can measure vital signs at an accuracy level matching those of point-of-care tests are presented. In particular, the focus of this review is placed on wearable sensors for measuring respiratory behavior, body temperature, and blood oxygen level, which are identified as the critical signals for diagnosing and monitoring Covid-19. Various designs based on different materials and working mechanisms are summarized. This review is concluded by identifying the remaining challenges and future opportunities for this emerging field.