Atención farmacéutica geriátrica / Pharmaceutical care process in aged

Los problemas relacionados con los medicamentosson causa frecuente de accidentes enlas personas mayores. Suponen un número importantede los ingresos hospitalarios y causa demuerte. Este hecho, unido a que el consumo demedicamentos y material sanitario incrementapaulatinamente el gasto farmacéutico de estegrupo de población, hace imprescindible la profesionalizaciónde la Atención Farmacéutica Geriátricacon el objetivo de minimizar los problemas,mejorar la eficiencia y por tanto mejorar lacalidad de vida de las personas mayores y disminuirel gasto sanitario. En este articulo se explicala estructuración del proceso de atención farmacéuticaen las organizaciones sociosanitarias deFundación Matia

The problems related with drug therapy are thefrequent reason of accidents in elderly people.They are supposed to be a big number of hospitaladmittances and death cause. This fact, linkedto the consumption of drugs and sanitary materialincreases gradually the pharmaceutical cost ofthis group of population, makes essential to professionalizethe Geriatric Pharmaceutical Carewith the objective of minimize the problems, improvethe efficiency and therefore improve thequality of life of elderly people and diminish thesanitary cost. In this article Matia`s Foundationexperience in the Pharmaceutical geriatric careprocess is described

Producing transglutaminases by molecular farming in plants: minireview article.

Transglutaminases have a range of catalytic activities, most of which concern the post-translational modification of proteins. The most important of these activities, both in terms of biology and biotechnology, is the cross-linking of proteins into large supramolecular networks. The widespread use of transglutaminases in research, medicine and industry has increased the demand for an inexpensive, efficient and safe source of recombinant enzymes. We describe initial results concerning the production of a mammalian transglutaminase in transgenic rice plants as a first step towards the large-scale molecular farming of this enzyme.

Transgenic rice as a vehicle for the production of the industrial enzyme transglutaminase.

Transglutaminases have a range of catalytic activities, most of which concern the post-translational modification of proteins. The most important of these activities is the cross-linking of proteins into large supramolecular networks. The widespread use of transglutaminases has increased the demand for an inexpensive, efficient and safe source of recombinant enzyme. We explored the use of plant-based systems for the production of this important industrial enzyme. Transgenic rice plants engineered with a rat prostate transglutaminase (rTGp), driven by the strong constitutive maize-1 ubiquitin promoter and its first intron, were shown to express the recombinant enzyme at the mRNA and protein levels. The Ca2+ dependence of the recombinant enzyme was confirmed by the biotin-labelled cadaverine-incorporation assay. In this communication we report the molecular and biochemical characterisation of transgenic plants expressing rTGp and this sets the stage for establishing a bioreactor system for the production of transglutaminases in plants.