Assuntos
Córtex Cerebral/efeitos dos fármacos , Circulação Cerebrovascular/efeitos dos fármacos , Pentoxifilina/uso terapêutico , Ressuscitação , Teobromina/análogos & derivados , Animais , Córtex Cerebral/fisiopatologia , Cães , Avaliação Pré-Clínica de Medicamentos , Eletroencefalografia , Feminino , Masculino , Fatores de TempoAssuntos
Barbitúricos/uso terapêutico , Isquemia Encefálica/tratamento farmacológico , Hipóxia Encefálica/tratamento farmacológico , Ressuscitação , Adulto , Animais , Encéfalo/metabolismo , Isquemia Encefálica/fisiopatologia , Gatos , Membrana Celular/enzimologia , Criança , Cães , Ativação Enzimática/efeitos dos fármacos , Glicosaminoglicanos/metabolismo , Haplorrinos , Humanos , Hipóxia Encefálica/fisiopatologia , Pessoa de Meia-Idade , Consumo de Oxigênio/efeitos dos fármacos , ATPase Trocadora de Sódio-Potássio/metabolismoAssuntos
Encéfalo/metabolismo , Morte Súbita , Plasma/fisiologia , Ressuscitação , Animais , Encéfalo/patologia , CãesAssuntos
Encéfalo/metabolismo , Ressuscitação , Animais , Morte , Cães , Ativação Enzimática , Feminino , Histocitoquímica , Masculino , Fatores de TempoRESUMO
Polyglucine infusions (10 ml/kg) during the first 10 days of postresuscitation period after 4-hour hypovolemic hypotension promotes normalization of general RNA content, quick mobile protein fractions, corresponding prealbumins, albumins, postalbumins, ceruloplasmin, transferrin, and alpha-globulins. Macromolecular protein fractions beta- and gamma-globulins--remained considerably changed: beta-globulins doubled, and gamma-globulins decreased 1.7-fold. Acid phosphatase specific activity increased in the postmitochondrial supernatant by 53%; an increase in the acid phosphatase activity was revealed in the neurons, glia, and vascular endothelium. The amount of Purkinje's cells in the cerebral cortex in the experimental group did not differ essentially from the control values. Thus, the results obtained emphasize the importance of prolonged polyglucine infusions together with other resuscitation measures in the treatment of hypovolemic states.
Assuntos
Encefalopatias/prevenção & controle , Córtex Cerebral/análise , Dextranos/administração & dosagem , Ressuscitação , Fosfatase Ácida/metabolismo , Animais , Córtex Cerebral/enzimologia , DNA/análise , Cães , Feminino , Histocitoquímica , Masculino , Proteínas do Tecido Nervoso/análise , RNA/análiseRESUMO
The author studied substances related to acetylcholine metabolism (acetylcholinesterase, non-specific acetylcholinesterase, SH, SS-groups, histidine, Ca) using histochemical methods. There was an increase in the intensity of reactions on SH-groups and Ca, and a rise in the staining degree on SS-groups and acetylcholinesterase in the subconvulsive phase of the stroke. These shifts were more significant in the brain stem. A generalization of convulsive strokes intensifies the given changes and causes an increase of the intensity of the reactions on histidine after the end of the stroke (after 1, 3, 6, 24, 48 and 72 hours). A normalization of the studied reactions happens at different times in the different brain areas and does not end completely even 72 hours following discontinuance of the convulsions. The author comes to the conclusion that the acetylcholine metabolism is inhibited during the covulsive stroke.
