Assuntos
Papillomaviridae/isolamento & purificação , Infecções por Papillomavirus/diagnóstico , Lesões Pré-Cancerosas/patologia , Infecções Tumorais por Vírus/diagnóstico , Condiloma Acuminado/diagnóstico , Condiloma Acuminado/epidemiologia , Condiloma Acuminado/terapia , Feminino , Humanos , Incidência , Masculino , Infecções por Papillomavirus/epidemiologia , Infecções por Papillomavirus/terapia , Lesões Pré-Cancerosas/epidemiologia , Prevenção Primária/métodos , Prognóstico , Medição de Risco , Infecções Tumorais por Vírus/epidemiologia , Infecções Tumorais por Vírus/terapiaAssuntos
Doenças do Sistema Nervoso Central/etiologia , Neurofibromatose 1/complicações , Doenças do Sistema Nervoso Central/diagnóstico por imagem , Doenças do Sistema Nervoso Central/patologia , Humanos , Imageamento por Ressonância Magnética , Neurofibromatose 1/diagnóstico por imagem , Neurofibromatose 1/patologia , Dermatopatias/diagnóstico por imagem , Dermatopatias/etiologia , Dermatopatias/patologia , Tomografia Computadorizada por Raios XAssuntos
Histiocitose de Células de Langerhans/diagnóstico por imagem , Crânio/patologia , Adolescente , Adulto , Idade de Início , Perda do Osso Alveolar/diagnóstico por imagem , Perda do Osso Alveolar/etiologia , Criança , Pré-Escolar , Diagnóstico Diferencial , Histiocitose de Células de Langerhans/diagnóstico , Humanos , Lactente , Recém-Nascido , Arcada Osseodentária/diagnóstico por imagem , Arcada Osseodentária/patologia , Imageamento por Ressonância Magnética , Doenças Mandibulares/diagnóstico por imagem , Doenças Mandibulares/etiologia , Radiografia , Crânio/diagnóstico por imagem , Perda de Dente/etiologiaAssuntos
Encéfalo/patologia , Incontinência Pigmentar/diagnóstico por imagem , Doenças do Nervo Óptico/patologia , Corpo Caloso/patologia , Humanos , Incontinência Pigmentar/patologia , Imageamento por Ressonância Magnética , Doenças do Nervo Óptico/etiologia , Tomografia Computadorizada por Raios XRESUMO
BACKGROUND: Lobular capillary hemangiomas (pyogenic granulomas) occur on both mucosal and cutaneous surfaces. There are conflicting data regarding the increased prevalence of lobular capillary hemangiomas in female versus male subjects. Some studies have noted a female predominance of lobular capillary hemangiomas, but other studies do not reveal such a disparity. Because of an increased prevalence during pregnancy, oral tumors are also known as "granuloma gravidarum" or "pregnancy tumors." A hormonal influence for these mucosal lesions has been postulated. There are, however, no studies that address a possible relationship between hormones and cutaneous lesions. OBJECTIVE: This study presents the epidemiology of lobular capillary hemangiomas, with an emphasis on cutaneous lesions. METHODS: We reviewed 63,759 dermatopathology reports from a regional, private dermatopathology laboratory and found 325 cases of lobular capillary hemangiomas over a 1-year period. RESULTS: In our study of lobular capillary hemangiomas, cutaneous lesions accounted for 86%, with mucosal lesions representing only 12% of cases. Seven cases were excluded (one was intravascular, two were subcutaneous, and in 4 the location was not specified). Overall, male patients outnumbered female patients. The peak incidence for cutaneous lobular capillary hemangiomas was found in the second decade of life. The most common cutaneous sites were the trunk, upper extremities, and head. Mucosal lesions were primarily seen on the lips, gingiva, and tongue, and these affected females more than males by a ratio of 2:1, most commonly in the fourth decade of life. CONCLUSION: Cutaneous lobular capillary hemangiomas were equally prevalent in male and female patients. This would refute a female hormonal influence in the induction of cutaneous lobular capillary hemangiomas. Our data may suggest a hormonal influence on mucosal lesions because mucosal lobular capillary hemangiomas were twice as common in female patients. However, the small number of lesions in our study precludes us from making such a conclusion.
Assuntos
Granuloma Piogênico/epidemiologia , Complicações na Gravidez/epidemiologia , Dermatopatias/epidemiologia , Pele/patologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Estudos Epidemiológicos , Feminino , Granuloma Piogênico/patologia , Humanos , Incidência , Lactente , Masculino , Pessoa de Meia-Idade , Mucosa/patologia , Gravidez , Complicações na Gravidez/patologia , Fatores Sexuais , Dermatopatias/patologiaAssuntos
Dermatoses Faciais/patologia , Hiperplasia Gengival/patologia , Granulomatose com Poliangiite/diagnóstico , Adulto , Diagnóstico Diferencial , Dermatoses Faciais/etiologia , Hiperplasia Gengival/etiologia , Granulomatose com Poliangiite/complicações , Granulomatose com Poliangiite/patologia , Humanos , MasculinoRESUMO
Bartonella henselae and B. quintana induce an unusual vascular proliferative tissue response known as bacillary angiomatosis (BA) and bacillary peliosis (BP) in some human hosts. The mechanisms of Bartonella-associated vascular proliferation remain unclear. Although host factors probably play a role, microbial coinfection has not been ruled out. Because of the vascular proliferative characteristics noted in both Kaposi's sarcoma (KS) and BA and occasional colocalization of KS and BA, the possibility was explored that KS-associated herpesvirus (KSHV) might be associated with BA lesions. Tissues with BA and positive and negative control tissues were tested for the presence of KSHV DNA by a sensitive polymerase chain reaction assay. Only 1 of 10 BA tissues, a splenic biopsy, was positive in this assay; this tissue was from a patient with concomitant KS of the skin. Thus, KSHV is probably not involved in the vascular proliferative response seen in BA-BP.
Assuntos
Angiomatose Bacilar/patologia , DNA Viral/análise , Herpesvirus Humano 8/isolamento & purificação , Peliose Hepática/patologia , Adulto , Angiomatose Bacilar/virologia , Bartonella/isolamento & purificação , DNA Bacteriano/análise , DNA Ribossômico/análise , Homossexualidade Masculina , Humanos , Masculino , Peliose Hepática/microbiologia , Peliose Hepática/virologia , Reação em Cadeia da Polimerase , RNA Ribossômico 18S/genéticaRESUMO
Proliferative verrucous leukoplakia (PVL) is a distinct variant of oral leukoplakia characterized by a high rate of malignant transformation. Histologic features are variable and range from epithelial dysplasia to verrucous squamous cell carcinoma. To our knowledge, there have been no previous reports of cutaneous PVL. We present an interesting case of PVL involving the skin.
Assuntos
Leucoplasia Oral/complicações , Dermatopatias/etiologia , Idoso , Biópsia , Doença Crônica , Diagnóstico Diferencial , Feminino , Humanos , Leucoplasia Oral/patologia , Orofaringe/patologia , Pele/patologia , Dermatopatias/patologiaRESUMO
Benign tumors of the vulva, although relatively uncommon, are often referred to dermatologists for evaluation and treatment. The clinical features of benign tumors may overlap with malignant neoplasms, and therefore, a biopsy is often necessary to make a definitive diagnosis. This article discusses benign tumors of the vulva that are not associated with infectious agents and presents their classification according to cell of origin.
Assuntos
Neoplasias Vulvares/diagnóstico , Adenoma de Glândula Sudorípara/diagnóstico , Biópsia , Dermatite Seborreica/diagnóstico , Diagnóstico Diferencial , Endometriose/diagnóstico , Feminino , Tumor de Células Granulares/diagnóstico , Hemangioma/diagnóstico , Histiocitoma Fibroso Benigno/diagnóstico , Humanos , Leiomioma/diagnóstico , Lipoma/diagnóstico , Linfangioma/diagnóstico , Neurofibroma/diagnóstico , Nevo/diagnóstico , Pólipos/diagnóstico , Neoplasias Vulvares/classificação , Neoplasias Vulvares/patologia , Neoplasias Vulvares/cirurgiaRESUMO
OBJECTIVES: Mucocutaneous diseases are common in patients infected with human immunodeficiency virus (HIV). To identify cutaneous diseases for which HIV-infected people are at high risk, we sought those that are strongly associated with specific HIV-related oral lesions and with progression of HIV disease. DESIGN: A cross-sectional study of HIV-positive outpatients referred to a university stomatology clinic for diagnosis and treatment of oral diseases. Each subject underwent both complete oral and cutaneous examinations. RESULTS: Among 55 men, with a median age of 41 years and a median CD4 cell count of 125/microliter (range 0-950/microliter), 93% had active oral diseases or conditions, including candidiasis, hairy leukoplakia, ulcers, Kaposi's sarcoma (KS), and xerostomia, and 95% had skin conditions, including onychomycosis, dermatophytosis, seborrheic dermatitis, KS, folliculitis, xerosis, and molluscum contagiosum. Seborrheic dermatitis, xerosis, skin KS, and molluscum contagiosum were associated with oral HIV-sentinel lesions (oral candidiasis, hairy leukoplakia, and KS), with low CD4 cell counts, and with AIDS. CONCLUSION: Our results suggest that xerosis and seborrheic dermatitis may be early harbingers of HIV disease progression. Their roles as predictors warrant further study, based on their associations with low CD4 cell counts and AIDS and strong co-prevalence with one of the most common HIV-related oral lesions, oral candidiasis.
Assuntos
Infecções Oportunistas Relacionadas com a AIDS , Infecções por HIV/complicações , Doenças da Boca/etiologia , Dermatopatias/etiologia , Síndrome da Imunodeficiência Adquirida/complicações , Adulto , Idoso , Contagem de Linfócito CD4 , Candidíase Bucal/etiologia , Estudos Transversais , Dermatite Seborreica/etiologia , Dermatomicoses/etiologia , Progressão da Doença , Foliculite/etiologia , Humanos , Ictiose/etiologia , Hospedeiro Imunocomprometido , Leucoplasia Pilosa/etiologia , Masculino , Pessoa de Meia-Idade , Molusco Contagioso/etiologia , Razão de Chances , Sarcoma de Kaposi/etiologia , Estatísticas não ParamétricasRESUMO
Many diseases present with both neurologic and dermatologic manifestations. Eight such clinical cases are presented, along with clinical photographs of the skin lesions, in the format of a self-evaluation. Each case is followed by a discussion and a brief review of the characteristic cutaneous and neurologic findings. The intent is to demonstrate classic dermatologic manifestations of diseases seen by neurologists.
Assuntos
Doenças do Sistema Nervoso/complicações , Doenças do Sistema Nervoso/diagnóstico , Dermatopatias/diagnóstico , Dermatopatias/etiologia , Adulto , Anticonvulsivantes/imunologia , Criança , Hipersensibilidade a Drogas/diagnóstico , Feminino , Humanos , Doença de Lyme/diagnóstico , Masculino , Meningite Meningocócica/diagnóstico , Pessoa de Meia-Idade , Mieloma Múltiplo/diagnóstico , Síndrome POEMS/diagnóstico , Febre Maculosa das Montanhas Rochosas/diagnóstico , Sífilis/diagnóstico , Esclerose Tuberosa/diagnósticoRESUMO
EPIDEMIOLOGY: Is the study of disease occurrence in human populations. As a science, epidemiology emphasizes descriptive and analytic observation, clinical trial, behavioral intervention, and the practical utility of diagnostic tests. "Epidemiology" is derived from the Greek epi (among), demos (people), and logos (doctrine). CLINICAL EPIDEMIOLOGY: Is the application of epidemiologic principles and methods to problems arising in clinical medicine, dermatology included. For dermatologists, understanding this discipline is as important as mastering other basic sciences, such as immunology, microbiology, and dermatopathology. The recognization of Lyme disease is a classic work of "infectious" disease epidemiology. In 1972, a disease characterized by erythema chronicum migrans and "endemic arthritis" clustered in Lyme, Connecticut. By 1975, an infectious agent was suspected to be the cause of the disease. In 1977, the tick was thought to be the vector; in 1980, the spirochete became the prime suspect and, in 1982, Borrelia burgdorferi was identified as the etiologic agent. The study of hexachlorobenzene exposure, resulting in porphyria turcica, is an example of classic "chronic" disease epidemiology. The illness began in 1955 when sporadic cases of porphyria occurred in eastern Turkey. In 1957, the first case with illness resembling congenital erythropoietic porphyria was described. In subsequent years, over 3000 patients developed "epidemic" porphyria. The cause was due to the ingestion of seed wheat which had been treated with fungicides containing 20% hexachlorobenzene. EPIDEMIOLOGIC METHODS: For research, published elsewhere as Dermatoepidemiology. I., include descriptive observational study, analytic observational study, epidemiologic experimental study and tests for sensitivity, specificity, and positive/negative predictive value. Epidemiologic principles, instead, stress the correct interpretation of data, minimization of bias, and the appreciation of natural variations in collected data.