RESUMO
A novel class of pyridinium and benzimidazolium chloride has been obtained in high yield. The antimicrobial activities of three homologous series of pyridinium and benzimidazolium chlorides against cocci, rods, fungi and bacillus have been measured. The antimicrobial activities of N,N'-bis[3-(1-alkoxymethyl)pyridinium chloride]methylenediamines, 1-undecyloxymethyl-3-(1-benzimidazolmethylamino)pyridinium, 1-undecyloxymethyl- and 1-dodecyloxymethyl-3-[1(benzotriazol-1-yl)methylamino]pyridinium chlorides exhibited strong activity and wide antibacterial spectra similar to the activity of benzalkonium chloride.
Assuntos
Antibacterianos/síntese química , Antibacterianos/farmacologia , Compostos de Piridínio/síntese química , Compostos de Piridínio/farmacologia , Alcanos/síntese química , Benzimidazóis/química , Benzimidazóis/farmacologia , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Mycobacterium tuberculosis/efeitos dos fármacosRESUMO
The copper(II) complexes with 1-alkylimidazole were prepared. Bactericidal properties of the obtained complexes against Staphylococcus aureus, Micrococcus luteus and Pseudomonas aeruginosa were studied. Particularly high activity against microbial strains was shown by complex [Cu(1-C4H9Im)4(CIO4)2].
Assuntos
Antibacterianos/farmacologia , Cobre/farmacologia , Imidazóis/farmacologia , Antibacterianos/química , Cobre/química , Imidazóis/química , Testes de Sensibilidade Microbiana , Micrococcus luteus/efeitos dos fármacos , Compostos Organometálicos/química , Compostos Organometálicos/farmacologia , Pseudomonas aeruginosa/efeitos dos fármacos , Staphylococcus aureus/efeitos dos fármacosRESUMO
New glycoprotein (CML) isolated from Chelidonium maius exhibits good antibacterial activity against methicillin resistant staphylococci and enterococci. It may constitute new antimicrobial agent against methicillin and vancomycin-resistant staphylococci as well as multiresistant enterococci.
Assuntos
Enterococcus/efeitos dos fármacos , Glicoproteínas/farmacologia , Lectinas/farmacologia , Papaver/química , Proteínas de Plantas/farmacologia , Plantas Medicinais , Staphylococcus/efeitos dos fármacos , Resistência a Múltiplos Medicamentos , Humanos , Resistência a Meticilina , Testes de Sensibilidade Microbiana , Lectinas de PlantasRESUMO
Decyldimethylamine reacts readily with chloromethylalkyl ethers of sulfides, chloromethylbenzyl ethers or sulfides and chloromethylcycloalkyl ethers to give quaternary ammonium chlorides in very good yields. All the chlorides studied showed antimicrobial activity. The relationship between the chemical structure and antimicrobial activity was analyzed by rough sets.