[Effect of nooglutil on rats with intracerebral posttraumatic hematoma (hemorrhagic stroke)]. / Effekt noogliutila u krys s intratserebral'noi postravmaticheskoi gematomoi (gemorragicheskim insul'tom).

The effect of the new nootropic drug nooglutyl, a positive modulator of AMPA-subtype glutamatergic receptors, was studied in rats with a model hemorrhagic stroke (HS)--posttraumatic hematoma induced by cerebral tissue destruction in the capsule interna region. Single intraperitoneal injections of nooglutyl (10 and 20 mg/kg) 3-4 h after operation decreased the HS-induced neurological deficiency, restored the coordination of movements, improved the passive avoidance reaction retrieval, and prevented the loss of experimental animals. The results show evidence of a pronounced neuroprotector action of nooglutyl in rats with the HS model.

[Comparative study of dilceren (nimodipine) on the cerebral circulation in the intact animals and animals subjected to ischemic brain damage]. / Sravnitel'noe izuchenie diltserena (nimodipina) na mozgovoe krovoobrashchenie intaktnykh zhivotnykh i posle global'nogo ishemicheskogo porazheniia mozga.

The influence of the calcium entry blocker dilceren (nimodipine) on the local and regional circulation was studied in rats and cats. In the majority of experiments on intact animals, dilceren increased the local and regional blood flow. However, in some cases, the circulation decreased or remained unchanged, which was accompanied by pronounced hypotension. Administered after global brain ischemia, dilceren improved the cerebral hemodynamics in all experiments.