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Biotechnol Bioeng ; 71(1): 28-37, 2000.
Artigo em Inglês | MEDLINE | ID: mdl-10629533

RESUMO

Using a combination of solid phase synthesis for the preparation of N-substituted-N-acylglycines 7 followed by solution-phase ring transformation of trifluoromethylacyl munchnone intermediate 8, a library of 200 trisubstituted-5-trifluoromethylketo (TFMK) imidazoles 9 was prepared. In a sublibrary, bromoacetate resin 4 was treated with 5 amines in parallel to give N-substituted glycines 5 followed by acylation with 12 acid chlorides to provide, upon cleavage from the resin, 60 individual N-substituted-N-acylglycines 7. The glycines 7 were converted to munchnones 8 by treatment with trifluoroacetic anhydride followed by reaction with benzamidine to give trisubstituted-5-TFMK-imidazoles 9. The structural content of the library was analyzed using PlateView of the LCMS results, and individual members were isolated by automated preparative LCMS.


Assuntos
Glicina/análogos & derivados , Glicina/síntese química , Imidazóis/síntese química , Bases de Dados como Assunto , Glicina/química , Imidazóis/química , Indicadores e Reagentes , Cetonas/síntese química , Cetonas/química , Modelos Moleculares , Resinas Vegetais
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