RESUMO
Type 2 Diabetes (T2D) is characterized by relative insulin insufficiency, caused when peripheral tissues such as liver, muscle, and adipocytes have a decreased response to insulin. One factor that elevates the risk for insulin resistance and T2D is obesity. In obese patients without T2D and initially in people who develop T2D, pancreatic ß-cells are able to compensate for insulin resistance by increasing ß-cell mass, effected by increased proliferation and hypertrophy, as well as increased insulin secretion per ß-cell. In patients that go on to develop T2D, however, this initial period of compensation is followed by ß-cell failure due to decreased proliferation and increased apoptosis. The forkhead box transcription factor FoxM1 is required for ß-cell replication in mice after four weeks of age, during pregnancy, and after partial pancreatectomy. We investigated whether it is also required for ß-cell proliferation due to diet-induced obesity.
