[The results of the multicenter pharmaco-epidemiological observational project on the use of mydocalm in the treatment of pain syndromes with the muscle spasm].

The prospective multicenter open noncomparative pharmaco-epidemiological observational project on the use of mydocalm in real clinical practice has been completed in 2013. The project has been performed in 2090 clinical/rehabilitation settings in 284 cities of 13 countries using the results of 35,383 patients. The project aimed to assess the safety of treatment (percentage of patients with adverse-effects) and pain relieving efficacy as well as patient's satisfaction with the treatment. In total, 6603 (19%) adverse-effects were recorded. Their severity was evaluated as mild in 84,48%, no serious adverse-effects were noted. The high efficacy of mydocalm in the treatment of pain syndromes with the muscle spasm has been demonstrated. The high level of tolerability and absence of the clinically significant increase of adverse effects in the combination with nonsteroidal anti-inflammatory drugs have been confirmed.

[Functional state of vision system under chronic mercury intoxication].

Examination of chronic mercury intoxication patients in distant (post-contact) period revealed marked vision disorders and inhibited neuro-conductivity--inhibited neuronal structures of retina and optic nerve.

[Disorders of mental function in patients with circulatory encephalopathy due to hypertension and atherosclerosis]. / Narusheniia nekotorykh psikhicheskikh funktsii u bol'nykh distsirkuliatornoi éntsefalopatiei, obuslovlennoi gipertonicheskoi bolezn'iu i aterosklerozom.

The authors described the dynamics of disorders of memory, attention and thinking in the course of treatment of patients with circulatory encephalopathy. It was shown that treatment resulted a prevailing regression of neurodynamic disorders of the higher psychic functions that was more productive at early stages of cerebrovascular insufficiency.

[Status of cerebral and central hemodynamics in patients with dyscirculatory encephalopathy]. / Sostoianie tserebral'noi i tsentral'noi gemodinamiki u bol'nykh distsirkuliatornoi éntsefalopatiei.

On the basis of radiocardiographic and radiocirculatory examination of the central and cerebral hemodynamics in 130 patients with dyscirculatory encephalopathy (DE) caused by essential hypertension and atherosclerosis, the authors have demonstrated that the development of DE is facilitated by disturbances of the central and peripheral hemodynamics. In turn, DE reduces the function of the autoregulatory mechanisms of the cerebral blood flow and leads to insufficiency of compensatory adaptive possibilities of the cardiovascular system. It is recommended that not only cerebral disorders but also the type (hyperkinetic, hypokinetic, eukinetic) of the blood circulation in these patients be taken into consideration in selecting the optimal method of treatment.

[Quantitative analysis of circulatory radiograms using computers]. / Kolichestvennyi analiz radiotsirkulogramm s ispol'zovaniem EVM.

A technique of quantitative RCG analysis is proposed and tested. It enables the unbiased evaluation of regional hemodynamics phases and of the relation between blood flow rate in arterial and venous beds. The technique is based on calculating the first derivative of the radiocirculogram. The specially developed program may be executed by the computer (ZBM EC).