RESUMO
OBJECTIVE: To estimate frequencies of polymorphic variants of TP53 codon 72 in the Ukrainian population. MATERIALS AND METHODS: We determined the allele frequencies for 148 healthy people. Genotyping was performed by allele specific polymerase chain reaction. RESULTS: We identified 31 individuals (20.9 %) with Arg/Arg genotype, Arg/Pro genotype was identified for 116 indi viduals (78.4 %), whereas genotype Pro/Pro was rare and was found in one person only (0.7 %). Genotype distribu tions were not within Hardy Weinberg equilibrium (χ2 = 59,7, p < 0.0001). CONCLUSIONS: Arg and Pro allele frequencies in the population of Ukraine are 60 and 40 % respectively, which is sig nificantly differ from the frequencies described in the literature for Poland, the Czech Republic, the USA and Brazil.