Development of Medical Sensor Systems in Pulmonology Based on Electrical Impedance Measurement.

In order to experimentally confirm the dependence of the bioelectrical impedance on the flow rate of charged aerosol particles and the composition of bronchial secretions in small airways, the electrical impedance of an aerosol of 0.9% NaCl solution in polyethylene tubes of various diameters was studied. The electrical impedance was also measured in cylindrical chambers of various diameters and volumes filled with a 0.9% NaCl solution or a gelatin solution. The studies were carried out at frequencies of alternating electric current from 20 Hz to 150 kHz. It was shown that the electrical current is not recorded in the absence of a flow of aerosol particles, and the impedance decreases with an increase in the flow velocity. The impedance modulus and the phase angle of the electrical impedance has an expressed dependence on the composition of the conductive medium, the impedance modulus increases in the gelatin solution medium, with a decrease in the diameter of the electric current conductor, and decreases with an increase in the frequency of the probing alternating current. The obtained results confirmed the hypothesis about the influence of the speed of salty aerosol particles flow and the composition of bronchial secretions on the results of measuring electrical impedance.

Chronic obstructive pulmonary disease patients electronic register analysis: the effectiveness of patient's dynamic follow up and evaluation of treatment program.

AIM: The aim of the study. To estimate the effectiveness of clinical patients register implementation as well as to analyze different treatment and prophylactic programs on chronic obstructive pulmonary disease (COPD) patients' structure. MATERIALS AND METHODS: The COPD patient's register consists of 4257 cases. Spirometrical data were evaluated. Dynamic follow was performed on 567 COPD patients. Bronchodilator's therapy was estimated as well as combined inhaled corticosteroid/ long acting ß2-agonist medications and vaccination against pneumococcal infection. RESULTS: Computer program "Electronic polyclinic" proposed by the authors of this article is effective in precision of diagnostic decision making in cohort study, dynamic follow up after clinical symptoms, evaluation of instrumental and laboratory results, prophylactics and treatment effectiveness, "clinical patients registers" automatic formation using syndrome or nosological principle, checking the COPD patients in the group of those with bronchial obstruction. CONCLUSION: Positive effects of long-acting bronchodilator treatment on COPD exacerbation decreasing and more expressed effect of inhaled corticosteroid/ long acting ß2-agonists were confirmed. More interesting result was influence of vaccination against pneumococcal infection PCV13 (polyvalent conjugated vaccine) on exacerbation frequency and dyspnea severity.