AI-Enabled Smart Wristband Providing Real-Time Vital Signs and Stress Monitoring.

This work introduces the design, architecture, implementation, and testing of a low-cost and machine-learning-enabled device to be worn on the wrist. The suggested wearable device has been developed for use during emergency incidents of large passenger ship evacuations, and enables the real-time monitoring of the passengers' physiological state, and stress detection. Based on a properly preprocessed PPG signal, the device provides essential biometric data (pulse rate and oxygen saturation level) and an efficient unimodal machine learning pipeline. The stress detecting machine learning pipeline is based on ultra-short-term pulse rate variability, and has been successfully integrated into the microcontroller of the developed embedded device. As a result, the presented smart wristband is able to provide real-time stress detection. The stress detection system has been trained with the use of the publicly available WESAD dataset, and its performance has been tested through a two-stage process. Initially, evaluation of the lightweight machine learning pipeline on a previously unseen subset of the WESAD dataset was performed, reaching an accuracy score equal to 91%. Subsequently, external validation was conducted, through a dedicated laboratory study of 15 volunteers subjected to well-acknowledged cognitive stressors while wearing the smart wristband, which yielded an accuracy score equal to 76%.

Design and Implementation of a UAV-Based Airborne Computing Platform for Computer Vision and Machine Learning Applications.

Visual sensing of the environment is crucial for flying an unmanned aerial vehicle (UAV) and is a centerpiece of many related applications. The ability to run computer vision and machine learning algorithms onboard an unmanned aerial system (UAS) is becoming more of a necessity in an effort to alleviate the communication burden of high-resolution video streaming, to provide flying aids, such as obstacle avoidance and automated landing, and to create autonomous machines. Thus, there is a growing interest on the part of many researchers in developing and validating solutions that are suitable for deployment on a UAV system by following the general trend of edge processing and airborne computing, which transforms UAVs from moving sensors into intelligent nodes that are capable of local processing. In this paper, we present, in a rigorous way, the design and implementation of a 12.85 kg UAV system equipped with the necessary computational power and sensors to serve as a testbed for image processing and machine learning applications, explain the rationale behind our decisions, highlight selected implementation details, and showcase the usefulness of our system by providing an example of how a sample computer vision application can be deployed on our platform.

A Modular Repository-based Infrastructure for Simulation Model Storage and Execution Support in the Context of In Silico Oncology and In Silico Medicine.

The plethora of available disease prediction models and the ongoing process of their application into clinical practice - following their clinical validation - have created new needs regarding their efficient handling and exploitation. Consolidation of software implementations, descriptive information, and supportive tools in a single place, offering persistent storage as well as proper management of execution results, is a priority, especially with respect to the needs of large healthcare providers. At the same time, modelers should be able to access these storage facilities under special rights, in order to upgrade and maintain their work. In addition, the end users should be provided with all the necessary interfaces for model execution and effortless result retrieval. We therefore propose a software infrastructure, based on a tool, model and data repository that handles the storage of models and pertinent execution-related data, along with functionalities for execution management, communication with third-party applications, user-friendly interfaces to access and use the infrastructure with minimal effort and basic security features.

Numerical simulation of vascular tumour growth under antiangiogenic treatment: addressing the paradigm of single-agent bevacizumab therapy with the use of experimental data.

BACKGROUND: Antiangiogenic agents have been recently added to the oncological armamentarium with bevacizumab probably being the most popular representative in current clinical practice. The elucidation of the mode of action of these agents is a prerequisite for personalized prediction of antiangiogenic treatment response and selection of patients who may benefit from this kind of therapy. To this end, having used as a basis a preexisting continuous vascular tumour growth model which addresses the targeted nature of antiangiogenic treatment, we present a paper characterized by the following three features. First, the integration of a two-compartmental bevacizumab specific pharmacokinetic module into the core of the aforementioned preexisting model. Second, its mathematical modification in order to reproduce the asymptotic behaviour of tumour volume in the theoretical case of a total destruction of tumour neovasculature. Third, the exploitation of a range of published animal datasets pertaining to antitumour efficacy of bevacizumab on various tumour types (breast, lung, head and neck, colon). RESULTS: Results for both the unperturbed growth and the treatment module reveal qualitative similarities with experimental observations establishing the biologically acceptable behaviour of the model. The dynamics of the untreated tumour has been studied via a parameter analysis, revealing the role of each relevant input parameter to tumour evolution. The combined effect of endogenous proangiogenic and antiangiogenic factors on the angiogenic potential of a tumour is also studied, in order to capture the dynamics of molecular competition between the two key-players of tumoural angiogenesis. The adopted methodology also allows accounting for the newly recognized direct antitumour effect of the specific agent. CONCLUSIONS: Interesting observations have been made, suggesting a potential size-dependent tumour response to different treatment modalities and determining the relative timing of cytotoxic versus antiangiogenic agents administration. Insight into the comparative effectiveness of different antiangiogenic treatment strategies is revealed. The results of a series of in vivo experiments in mice bearing diverse types of tumours (breast, lung, head and neck, colon) and treated with bevacizumab are successfully reproduced, supporting thus the validity of the underlying model.

Web-based workflow planning platform supporting the design and execution of complex multiscale cancer models.

Significant Virtual Physiological Human efforts and projects have been concerned with cancer modeling, especially in the European Commission Seventh Framework research program, with the ambitious goal to approach personalized cancer simulation based on patient-specific data and thereby optimize therapy decisions in the clinical setting. However, building realistic in silico predictive models targeting the clinical practice requires interactive, synergetic approaches to integrate the currently fragmented efforts emanating from the systems biology and computational oncology communities all around the globe. To further this goal, we propose an intelligent graphical workflow planning system that exploits the multiscale and modular nature of cancer and allows building complex cancer models by intuitively linking/interchanging highly specialized models. The system adopts and extends current standardization efforts, key tools, and infrastructure in view of building a pool of reliable and reproducible models capable of improving current therapies and demonstrating the potential for clinical translation of these technologies.

Computational Horizons In Cancer (CHIC): Developing Meta- and Hyper-Multiscale Models and Repositories for In Silico Oncology - a Brief Technical Outline of the Project.

This paper briefly outlines the aim, the objectives, the architecture and the main building blocks of the ongoing large scale integrating transatlantic research project CHIC (http://chic-vph.eu/).