[Characteristics of the neuromodulating effect of peripherally administered thyroliberin on the rat brain]. / Osobennosti neiromoduliruiushchego deistviia perifericheski vvedennogo tiroliberina v strukturakh mozga krysy.

The study of TRH effect on monoaminergic processes (MP) in the rat brain areas (hypothalamus, striopallidar system, cortex) was carried out upon intramuscular administration of TRH in doses of 1, 5 and 10 mg/kg 0.5, 1 and 3 h after TRH injections the animals were decapitated. TRH was shown to elicit persisting (3 h) multidirectional MP alterations in catecholaminergic system and unidirectional alterations in serotoninergic system (mainly acceleration of serotonin turnover). The most marked influence is produced by the lowest TRH dose, 1 mg/kg. It is suggested that in spite of a short half-life (2-5 min) TRH is able to act as a modulator on different target points of the rat MP pathways. That could be one of the possible explanations of previously observed prolonged TRH-induced pharmacological and clinical effects.

[Comparison of structural and functional organization of adrenocorticotropic hormone and wasp kinin]. / Sravnenie strukturno-funktsional'noi organizatsii molekuly aktg i kinina iz iada osy

A comparative study of structural and functional organization of the polypeptides -- ACTH and wasp kinin was made. The effects of fragments Lys 17, 18-ACTH11(-18)-NH2--(I) and WK4(-12)--(II), possessing "common" fragments and a cluster of basic amino-acids, on the lipolytic and steroidogenic effects of ACTH and myotropic effects of bradykinin were studied. Both fragments I and II potentiate ACTH-induced lipolysis and steroidogenesis in isolated rat fat and adrenal cells but suppress the myotropic effect of bradykinin on guinea pig ileum. The similarity of biological effects of ACTH and WK fragments support our supposition on the similarity in structurally functional organization of these peptides.