Clinical characteristics and outcomes in CMV infection in intestinal transplant recipients: A single-center experience.

BACKGROUND: Cytomegalovirus (CMV) infection is one of the most common posttransplantation infections and has been associated with increased rejection and mortality. Data in intestinal transplants recipients are limited. METHODS: This is a single-center, retrospective cohort study of all intestinal transplants performed between January 1, 2009, and August 31, 2020. We included recipients of all ages who were at risk of CMV infection. To identify the risk factors, we conducted at first univariate and multivariate analysis. For the multivariate analysis, we developed a logistic regression model based on the result of univariate analysis. RESULTS: Ninety five patients with a median age of 32 (interquartile range [IQR] 4, 50) were included. CMV donor seropositive/recipient seronegative were 17 (17.9%). Overall, 22.1% of the recipients developed CMV infection at a median time of 155 (IQR 28-254) days from transplant, including 4 CMV syndrome and 6 CMV end-organ disease. Overall, 90.4%, (19/21) developed DNAemia while on prophylaxis. Median peak viral load and time to negativity was 16 000 (IQR 1034-43 892) IU/mL and 56 (IQR 49-109) days, respectively. (Val)ganciclovir and foscarnet were utilized in 17 (80.9%) and 1 (4.76%) recipients, respectively. Recurrences of CMV DNAemia and graft rejection were observed in three and six recipients, respectively. Younger age was identified as a risk factor (p = .032, odds ratio 0.97, 95% confidence interval 0.95-0.99) to develop CMV DNAemia. CONCLUSION: A significant proportion of intestinal transplant recipients developed CMV infection while on prophylaxis. Better methods such as CMV cell mediated immunity guided prophylaxis should be used to prevent infections in this population.

When is it safe to perform abdominal transplantation in patients with prior SARS-CoV-2 infection: A case series.

BACKGROUND: The Coronavirus disease 2019(COVID-19) pandemic has negatively impacted worldwide organ transplantation. However, there is limited information on recipients transplanted after SARS-CoV-2 infection. A full understanding of this scenario is required, as transplantation is a life-saving procedure and COVID-19 remains an ongoing threat. METHODS: Abdominal organ transplant recipients diagnosed with COVID-19 prior to transplantation were identified by chart review and clinical data were collected. The primary outcome was the transplant outcome including graft loss, rejection and death, and reactivation of infection post-transplant. RESULTS: We identified 14 patients who received abdominal organ transplants after symptomatic PCR confirmed SARS-CoV-2 infection; four patients had a positive PCR at the time of admission for transplantation. The median time of follow-up was 79 (22-190) days. One recipient with negative PCR before transplant tested positive 9 days after transplant. One of 14 transplanted patients developed disseminated mold infection and died 86 days after transplant. During the follow-up, only one patient developed rejection; thirteen patients had favorable graft outcomes. CONCLUSIONS: We were able to perform abdominal transplantation for patients with COVID-19 before transplant, even with positive PCR at the time of transplant. Larger studies are needed to determine the time to safe transplant after SARS-CoV-2 infection.

Menopausa, homens e imaginário: reflexões sobre uma intervenção fílmica realizada no centro da cidade de São Paulo / Menopause, men and the imaginary: reflections on a filmic intervention carried out in downtown São Paulo

A partir de 2002, dentro do Projeto Ondas, estivemos envolvidos em diferentes campos de pesquisa, investigando o tema "Menopausa e Envelhecimento". Buscávamos compreender o imaginário construído sobre a menopausa em nossa cultura, privilegiando o discurso de mulheres que, por suas condições sócio-econômica e cultural, distanciavam-se das "mulheres-target" das campanhas de medicamentos. Fossem índias, caiçaras ou mulheres da periferia de São Paulo, compreendíamos, através de suas falas, que suas marcas não vinham de ondas de calor, depressão ou da falta de libido e, sim, de suas condições de vida (ou sobrevivência) e das particularidades de seu cotidiano - o que evidenciou claramente uma diversidade de discursos, de vidas e, por quê não? de menopausas.

Coisa dos homens: relatos de uma intervenção fílmica sobre menopausa no centro de São Paulo / Men's stuff: reports of a filmic intervention about menopausa at downtown São Paulo / Cosa de los hombres: relato de una intervención filmica sobre la menopausa en el centro de la ciudad de São Paulo

Este artigo narra o processo de construção de uma intervenção fílmica realizada na Praça da Sé e na Praça do Carmo, centro de São Paulo, que teve como objetivo responder as seguintes questões: o que aconteceria se um camelô desse informações sobre a menopausa em um espaço público da cidade de São Paulo? Será que conseguiríamos filmar o que eventualmente poderia acontecer? À medida que o projeto ia sendo realizado e as filmagens aconteciam, foram surgindo além de imprevistos e surpresas, novos questionamentos, do tipo: como apresentar a diversidade dos discursos que surgiram? O que priorizar na edição? Como incorporar o nosso próprio amadurecimento, no decorrer do projeto a esse processo mais amplo de conhecimento? A fim de tratar desse campo de questões, introduzimos o artigo, abordando alguns aspectos da construção da menopausa em nossa cultura. A seguir, relatamos como foi construído o nosso dia-a-dia durante a realização do projeto. Por fim, na conclusão, fazemos algumas reflexões sobre a experiência realizada, e discutimos alguns aspectos a respeito da produção de filmes e vídeos na área da saúde, principalmente no atinente à relação estabelecida entre a imagem e a medicina(AU)

This work narrates the construction of a filmic intervention made in Praça da Sé and Praça do Carmo, in Sao Paulo downtown, which aimed to answer the following questions: what would happen if a peddler gave information about menopause in a public space in the city of Sao Paulo? Could we film what eventually happened? While the project was be¬ing realized and the shots were taken, along with some surprises, new questions arose, namely: how could we present the diversity of the discourses that appeared? To what should we give priority in the edition? How could we incorporate our own learning and achieved maturity to this wider process of knowledge? In order to deal with these matters, we start the article ap¬proaching some aspects of the concept of menopause in our culture. Afier that, we report how our daily activities were developed, and, finally, we propose some reflections about this experience, completing with a discussion on the production of movies and videos in the area of health, especially with respect to the relation between medicine and image(AU)

Coisa dos homens: relatos de uma intervenção fílmica sobre menopausa no centro de São Paulo

Este artigo narra o processo de construção de uma intervenção fílmica realizada na Praça da Sé e na Praça do Carmo, centro de São Paulo, que teve como objetivo responder as seguintes questões: o que aconteceria se um camelô desse informações sobre a menopausa em um espaço público da cidade de São Paulo? Será que conseguiríamos filmar o que eventualmente poderia acontecer? À medida que o projeto ia sendo realizado e as filmagens aconteciam, foram surgindo além de imprevistos e surpresas, novos questionamentos, do tipo: como apresentar a diversidade dos discursos que surgiram? O que priorizar na edição? Como incorporar o nosso próprio amadurecimento, no decorrer do projeto a esse processo mais amplo de conhecimento? A fim de tratar desse campo de questões, introduzimos o artigo, abordando alguns aspectos da construção da menopausa em nossa cultura. A seguir, relatamos como foi construído o nosso dia-a-dia durante a realização do projeto. Por fim, na conclusão, fazemos algumas reflexões sobre a experiência realizada, e discutimos alguns aspectos a respeito da produção de filmes e vídeos na área da saúde, principalmente no atinente à relação estabelecida entre a imagem e a medicina.

This work narrates the construction of a filmic intervention made in Praça da Sé and Praça do Carmo, in Sao Paulo downtown, which aimed to answer the following questions: what would happen if a peddler gave information about menopause in a public space in the city of Sao Paulo? Could we film what eventually happened? While the project was be¬ing realized and the shots were taken, along with some surprises, new questions arose, namely: how could we present the diversity of the discourses that appeared? To what should we give priority in the edition? How could we incorporate our own learning and achieved maturity to this wider process of knowledge? In order to deal with these matters, we start the article ap¬proaching some aspects of the concept of menopause in our culture. Afier that, we report how our daily activities were developed, and, finally, we propose some reflections about this experience, completing with a discussion on the production of movies and videos in the area of health, especially with respect to the relation between medicine and image.