Effects of stimulating the supplementary motor area with a transcranial alternating current for bimanual movement performance.

Transcranial alternating current stimulation (tACS) can regulate the frequency of neuronal activity in the cerebral cortex. Beta (ß) activity in the supplementary motor area (SMA) is involved in motor planning and maintenance while gamma (γ) activity is involved in updating motor plans. We investigated the effect of tACS in the ß- and γ-bands (ß-tACS and γ- tACS) applied to the SMA on bimanual movement performance. This study included 32 right-handed healthy participants performing a Purdue Pegboard Test (PPT) during the administration of either ß-tACS (20 Hz), γ-tACS (80 Hz), or sham stimulation over the SMA. Each participant performed nine PPT trials during each stimulation condition. The linear approximation of the number of parts and their differences for the 9 trials performed by each participant was calculated. A significant positive correlation was found between the difference from linear approximation for the ß-tACS condition and the intercept of the linear approximation (p = 0.007, Pearson's r = 0.464), and significant negative correlation was found for the γ-tACS condition (p = 0.012, Pearson's r = -0.438). In the low-performance subgroup, the mean values of the difference from linear approximation under the γ-tACS condition was significantly larger than that under the ß-tACS condition (p = 0.048). These results were opposite for the high-performance subgroup (p = 0.002) and sham group (p = 0.014). We demonstrated that the effect of tACS over the SMA depended on the stimulus frequency and the participant's motor performance and may modulate the maintenance and updating of motor plans.

Effects on motor learning of transcranial alternating current stimulation applied over the primary motor cortex and cerebellar hemisphere.

Transcranial alternating current stimulation (tACS) is a non-invasive method of brain stimulation that modulates oscillatory neural activity in the cortical area under the electrodes. Gamma (γ)-tACS applied over the primary motor cortex (M1) and cerebellar hemisphere is known to improve motor performance; however, it is not yet known whether it affects motor learning. Thus, here we investigated whether γ-tACS applied over the M1 and cerebellar hemisphere affects motor learning. This study involved 30 healthy subjects (14 females, 16 males) performing a visuomotor control task (eight trials) during an administration of either γ-tACS or a sham stimulation (15 subjects per condition) over their right M1 and left cerebellar hemisphere. Each subject performed five trials after 24 h. The motor learning efficiency, motor learning retention and re-motor learning efficiency in each condition were compared. The motor learning retention in the γ-tACS condition was significantly higher than that in the sham condition (p = 0.031). Thus, subjects who were administered γ-tACS maintained their motor performance the next day better than sham-stimulated subjects. There was no significant difference between the conditions in the motor learning efficiency and those in the re-motor learning efficiency. Our results demonstrate that γ-tACS administered over the M1 and cerebellar hemisphere during a motor learning task can enhance motor learning retention.