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1.
J UOEH ; 42(2): 203-208, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32507843

RESUMO

A 37-year-old Japanese man presented with a bulla with niveau-like opacity in the right upper lung on chest radiography. Air-fluid level gradually increased despite broad-spectrum antibiotic therapy. Right upper lobectomy was performed, and epithelioid granuloma with mycobacteria was histopathologically observed. Bacterial culture of the fluid was negative, but mycobacterial culture was positive for Mycobacterium avium; therefore, the patient was diagnosed with pulmonary infected bulla caused by Mycobacterium avium. He was further treated with antimycobacterial agents after resection of the infected bulla. To our knowledge, this is the first report of pulmonary infected bulla caused by only Mycobacterium avium in the English literature.


Assuntos
Vesícula/microbiologia , Pneumopatias/microbiologia , Infecção por Mycobacterium avium-intracellulare , Adulto , Antibacterianos , Vesícula/terapia , Humanos , Pneumopatias/terapia , Masculino , Pneumonectomia
2.
J UOEH ; 42(2): 223-227, 2020.
Artigo em Japonês | MEDLINE | ID: mdl-32507846

RESUMO

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been reported to be useful not only for the diagnosis of lymph node metastasis of lung cancer but also for benign diseases. We retrospectively analyzed the results of patients with tuberculous lymphadenitis (TL) who had undergone EBUS-TBNA between November 2010 and January 2016. EBUS-TBNA was performed in 427 cases during that period. Six cases were finally diagnosed as TL. The punctured lymph node was 8 lesions. Pathological findings consistent with TL were obtained in all 6 cases (100%), and the tissue specimens were positive in Ziehl-Neelsen staining in 3 of the 6 cases (50%). In all 6 cases, the acid-fast bacteria (AFB) smear test of the needle rinse fluid was negative, 2 cases were positive for AFB culture (33.3%), and 2 cases were positive for Mycobacterium tuberculosis (MTB)-PCR test (33.3%). In this study, the positive rate of mycobacterial culture and the MTB-PCR test of the needle rinse fluid was low, though the concordance rate of pathological findings with TL was high (100%). The results suggest that EBUS-TBNA should be carefully evaluated in patients with TL, considering the low positive rate of mycobacterial culture and MTB-PCR test in the needle rinse fluid.


Assuntos
Aspiração por Agulha Fina Guiada por Ultrassom Endoscópico/métodos , Tuberculose dos Linfonodos/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Tuberculose dos Linfonodos/diagnóstico por imagem
3.
J Toxicol Sci ; 28(5): 445-53, 2003 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-14746348

RESUMO

This study was designed to evaluate and characterize any subacute toxicity of 1-carboxy-5,7-dibromo-6-hydroxy-2,3,4-trichloroxanthone (HXCA), an impurity of Phloxine B (Food Red No. 104 in Japan, D&C Red No. 28 in the USA), when administered to both sexes of F344 rats at dietary levels of 0 (control), 0.005, 0.05 and 0.5%. During the study, the treatment had no effects on clinical signs, survival, urinalysis or ophthalmology. Hematology, blood biochemistry, gross pathology, organ weights, organ to body weight ratios and histopathology exhibited no differences of toxicological significance between control and treated rats. Reactions to treatment may be summarized as follows: there was a tendency for increased food and water consumption and decreased food efficiency in both sexes of the 0.5% group. Thus, these results indicated the no-observed-adverse-effect level (NOAEL) of HXCA to be 0.05% (39.3 mg/kg/day for males, and 41.0 mg/kg/day for females).


Assuntos
Azul de Eosina I/toxicidade , Corantes de Alimentos/toxicidade , Xantonas/toxicidade , Animais , Qualidade de Produtos para o Consumidor , Dieta , Relação Dose-Resposta a Droga , Ingestão de Líquidos/efeitos dos fármacos , Contaminação de Medicamentos , Ingestão de Alimentos/efeitos dos fármacos , Azul de Eosina I/química , Feminino , Concentração de Íons de Hidrogênio , Masculino , Nível de Efeito Adverso não Observado , Ratos , Ratos Endogâmicos F344 , Fatores de Tempo , Testes de Toxicidade , Urina/química , Xantonas/química , Xantonas/metabolismo
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