Assuntos
Núcleo Caudado/irrigação sanguínea , Hemorragia Cerebral/etiologia , Hipertensão/complicações , Núcleo Caudado/diagnóstico por imagem , Hemorragia Cerebral/diagnóstico , Hemorragia Cerebral/reabilitação , Feminino , Humanos , Hipertensão/diagnóstico , Hipertensão/tratamento farmacológico , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Radiografia , Resultado do TratamentoRESUMO
This case report describes an 11-year-old boy with primitive neuroectodermal tumor (PNET), which remains the pediatric brain tumor with the worst prognosis despite combination treatment with surgery, irradiation and anti-cancer drugs. The boy was successfully treated with intratumoral administration of interferon-beta (IFN-beta) following surgical resection and irradiation. Two million units of IFN-beta were locally administered into the post-operative cavity through the Ommaya's reservoir every two weeks after discharge. He was managed as an outpatient without serious side-effects to IFN. The patient has shown no tumor recurrence, mental retardation, or neuroendocrine impairment for over three years and has lived a normal school life with a full Karnofsky Performance Status score. The local administration of IFN-beta may be warranted for maintenance therapy in children with PNET.
Assuntos
Neoplasias Encefálicas/terapia , Interferon beta/administração & dosagem , Tumores Neuroectodérmicos Primitivos/terapia , Neoplasias Encefálicas/tratamento farmacológico , Neoplasias Encefálicas/radioterapia , Neoplasias Encefálicas/cirurgia , Cateteres de Demora , Criança , Terapia Combinada , Feminino , Humanos , Tumores Neuroectodérmicos Primitivos/tratamento farmacológico , Tumores Neuroectodérmicos Primitivos/radioterapia , Tumores Neuroectodérmicos Primitivos/cirurgiaRESUMO
We report a case of multiple hemorrhagic cerebral metastases from papillary thyroid cancer, with reference to T(2)*-weighted gradient echo (GRE) magnetic resonance imaging (MRI). Small metastatic nodules were recognized as round nodules with signal loss on T(2)*-weighted GRE MRI, and were more pronounced compared with other sequences. Lesions were later confirmed as hemorrhagic on T(1)- and T(2)-weighted MRI. T(2)*-weighted GRE MRI was a sensitive tool for early detection of metastases displaying hemorrhagic changes.
