1.
Bioorg Med Chem Lett
; 11(3): 395-8, 2001 Feb 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11212119
RESUMO
Highly potent 1,3-beta-D-glucan synthase inhibitors 10, 11 and 13 have been identified by the chemical modification of the fungicidal macrocyclic lipopeptidolactone, RO-09-3655 (1), isolated from the cultured broth of Deuteromycotinia spp. D-Ornithine derivative (10) showed improved antifungal activity in the systemic candidiasis model in mice and reduced hepatotoxicity in vitro, as compared with 1.