RESUMO
We treated an 82-year-old man with early gastric cancer using endoscopic submucosal resection.Ultrasonography, which was performed to screen for metastasis, revealed hepatocellular carcinoma, and the tumor was curatively resected.Ultrasonography can be considered a useful examination tool to detect double cancer, even in cases of early cancer.
Assuntos
Carcinoma Hepatocelular/diagnóstico por imagem , Neoplasias Hepáticas/diagnóstico por imagem , Neoplasias Primárias Múltiplas/diagnóstico por imagem , Neoplasias Gástricas/cirurgia , Idoso de 80 Anos ou mais , Carcinoma Hepatocelular/cirurgia , Detecção Precoce de Câncer , Ressecção Endoscópica de Mucosa , Hepatectomia , Humanos , Neoplasias Hepáticas/patologia , Neoplasias Hepáticas/cirurgia , Masculino , Neoplasias Primárias Múltiplas/cirurgia , UltrassonografiaRESUMO
We treated a 91-year-old man with squamous cell carcinoma that originated from his jejunum, which is very rare; only 8 cases have been reported previously.Surgery was performed because of the small bowel obstruction caused by the large cancerous mass, but he died 23 days later.Early detection and early treatment are important, especially for the ultra-elderly from a standpoint of tolerating surgery.
Assuntos
Carcinoma de Células Escamosas/diagnóstico por imagem , Neoplasias do Jejuno/diagnóstico por imagem , Idoso de 80 Anos ou mais , Carcinoma de Células Escamosas/complicações , Carcinoma de Células Escamosas/cirurgia , Evolução Fatal , Humanos , Obstrução Intestinal/etiologia , Neoplasias do Jejuno/complicações , Neoplasias do Jejuno/patologia , Neoplasias do Jejuno/cirurgia , Falência Hepática/complicações , Falência Hepática/fisiopatologia , MasculinoRESUMO
OBJECTIVES: The aim of the present study was to assess the appropriate administration dose of non-steroidal anti-inflammation drugs to prevent pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP). Importantly, the 100â mg dose of diclofenac recommended in Western countries has not been permitted in Japan. DESIGN: A retrospective study. SETTINGS: A single centre in Japan. PARTICIPANTS: This study enrolled patients who underwent ERCP at the Department of Gastroenterology, Osaka Saiseikai Senri Hospital, from April 2011 through June 2013, and who received either a 25 or a 50â mg dose of rectal diclofenac after ERCP. PRIMARY OUTCOME MEASURE: The occurrence of post-ERCP pancreatitis (PEP). A multivariate regression model was used to assess the effect of the 50â mg dose (the 50â mg group) of rectal diclofenac and to compare it to the occurrence of PEP referring to the 25â mg group. RESULTS: A total of 155 eligible patients received either 25â mg (84 patients) or 50â mg (71 patients) doses of rectal diclofenac after ERCP to prevent PEP. The proportion of PEP was significantly lower in the 50â mg group than in the 25â mg group (15.5% (11/71) vs 33.3% (28/84), p=0.018). In a multivariate analysis, the occurrence of PEP was significantly lower in the 50â mg group than in the 25â mg group even after adjusting potential confounding factors (adjusted OR=0.27, 95% CI 0.11 to 0.70). CONCLUSIONS: From this observation, the occurrence of PEP was significantly lower among ERCP patients with the 50â mg dose of rectal diclofenac than among those with the 25â mg dose.
Assuntos
Anti-Inflamatórios não Esteroides/administração & dosagem , Colangiopancreatografia Retrógrada Endoscópica/efeitos adversos , Diclofenaco/administração & dosagem , Pancreatite/prevenção & controle , Administração Retal , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Japão , Masculino , Pessoa de Meia-Idade , Pancreatite/etiologia , Estudos RetrospectivosRESUMO
The Golgi apparatus is important for the transport of secretory cargo. Glycosylation is a major post-translational event. Recognition of O-glycans on proteins is necessary for glycoprotein trafficking. In this study, specific inhibition of O-glycosylation (Golgi stress) induced the expression of endoplasmic reticulum (ER)-resident heat shock protein (HSP) 47 in NIH3T3 cells, although cell death was not induced by Golgi stress alone. When HSP47 expression was downregulated by siRNA, inhibition of O-glycosylation caused cell death. Three days after the induction of Golgi stress, the Golgi apparatus was disassembled, many vacuoles appeared near the Golgi apparatus and extended into the cytoplasm, the nuclei had split, and cell death assay-positive cells appeared. Six hours after the induction of Golgi stress, HSP47-knockdown cells exhibited increased cleavage of Golgi-resident caspase-2. Furthermore, activation of mitochondrial caspase-9 and ER-resident unfolded protein response (UPR)-related molecules and efflux of cytochrome c from the mitochondria to the cytoplasm was observed in HSP47-knockdown cells 24 h after the induction of Golgi stress. These findings indicate that (i) the ER-resident chaperon HSP47 protected cells from Golgi stress, and (ii) Golgi stress-induced cell death caused by the inhibition of HSP47 expression resulted from caspase-2 activation in the Golgi apparatus, extending to the ER and mitochondria.
Assuntos
Retículo Endoplasmático/metabolismo , Complexo de Golgi/metabolismo , Proteínas de Choque Térmico HSP47/metabolismo , Animais , Glicosilação , Camundongos , Mitocôndrias/metabolismo , Células NIH 3T3RESUMO
We treated a 41-year-old man with hepatocellular carcinoma and chronic liver disease. He experienced leg edema. Following additional examinations, we diagnosed the patient with hepatocellular carcinoma and ascites with liver cirrhosis. Due to renal dysfunction, he could not undergo treatment with transcatheter arterial chemoembolization(TACE)or transcatheter arterial infusion(TAI). Therefore, he was treated with specific substance of maruyama(SSM), and survived.
Assuntos
Vacinas Anticâncer/uso terapêutico , Carcinoma Hepatocelular/terapia , Cirrose Hepática/terapia , Neoplasias Hepáticas/terapia , Adulto , Ascite/etiologia , Carcinoma Hepatocelular/etiologia , Embolização Terapêutica , Humanos , Cirrose Hepática/complicações , Neoplasias Hepáticas/etiologia , MasculinoRESUMO
We treated an 80-year-old woman with gallbladder cancer. Because of her advanced age, chemotherapy was performed, but obstructive jaundice and duodenal stenosis were caused by invasion of the tumor. We inserted a metallic stent into the common bile duct and duodenum 3 times. As a result, she could eat and live at home with good quality of life.
Assuntos
Obstrução Duodenal/terapia , Neoplasias da Vesícula Biliar/patologia , Qualidade de Vida , Stents , Idoso de 80 Anos ou mais , Obstrução Duodenal/etiologia , Evolução Fatal , Feminino , Neoplasias da Vesícula Biliar/complicações , Humanos , Invasividade NeoplásicaRESUMO
We treated a 73-year-old woman with adenocarcinoma of the duodenum. She complained of poor appetite and weight loss. Upon close inspection, we diagnosed duodenal cancer with obstructive jaundice. Curative resection could not be performed because of swelling of the para-aortic lymph nodes. Chemotherapy using mFOLFOX6 was performed, and she survived.
Assuntos
Neoplasias Duodenais/tratamento farmacológico , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Feminino , Fluoruracila/administração & dosagem , Humanos , Leucovorina/administração & dosagem , Compostos Organoplatínicos/administração & dosagemRESUMO
Esohophageal stents are often used in treating malignant stricture. But, when stents are placed across the esophagogastric junction, they may lead to esophagogastric reflux. We report a case of successfully treated esophagogastric strictures using the new stent with anti-reflux mechanism (long cover type Niti-S™ esophageal stent). A 78-year-old man presenting with severe strictures from the lower esophagus to cardiac part of stomach was histopathologically diagnosed as adenocarcinoma. CT scan images showed multiple liver metastatic tumors. However, he refused chemotherapy. Palliation using long cover type Niti-S™ esophageal stent was performed. No adverse effect was occurred. He started solid meals on the 7th postoperative day. He was thereafter able to ingest solid meals without the symptom of esophgogastric reflux and stenosis until he died of the primary disease two month later.
Assuntos
Neoplasias Esofágicas/cirurgia , Estenose Esofágica/cirurgia , Junção Esofagogástrica/cirurgia , Refluxo Gastroesofágico/prevenção & controle , Cuidados Paliativos , Stents , Neoplasias Gástricas/cirurgia , Idoso , Neoplasias Esofágicas/complicações , Estenose Esofágica/etiologia , Evolução Fatal , Humanos , Masculino , Neoplasias Gástricas/complicações , Tomografia Computadorizada por Raios XRESUMO
A 32-year-old woman was admitted with intermittent rectal bleeding with disseminated intravascular coagulation (DIC)-like coagulopathy. CT and MRI revealed a retroperitoneal tumor, and we diagnosed giant retroperitoneal hemangioma complicated with Kasabach-Merritt syndrome, following blood pool scintigraphy. Corticosteroid and interferon-alpha were not effective, and gabexate mesilate was also ineffective for coagulopathy. Immediately after receiving danaparoid sodium, she recovered from DIC. We performed tumor resection successfully, and she had no symptoms of coagulopathy thereafter.
Assuntos
Anticoagulantes/uso terapêutico , Sulfatos de Condroitina/uso terapêutico , Dermatan Sulfato/uso terapêutico , Coagulação Intravascular Disseminada/tratamento farmacológico , Hemangioma/complicações , Heparitina Sulfato/uso terapêutico , Neoplasias Retroperitoneais/complicações , Adulto , Coagulação Intravascular Disseminada/complicações , Feminino , Hemangioma/cirurgia , Humanos , Neoplasias Retroperitoneais/cirurgiaRESUMO
Several myelin-derived proteins are inhibitory cues that contribute to the lack of regeneration of the CNS and inhibit neurite outgrowth from some neurons in vitro. This inhibition is blocked if neurons are exposed to neurotrophins before encountering the inhibitors. Here, we demonstrate that chimaerin, one of the Rho GTPase activating proteins, is transcriptionally up-regulated after exposure to neurotrophins in post-natal cerebellar neurons. The expression of alpha chimaerin in the cerebellum is developmentally correlated with the abolishment of the inhibitory effect of myelin-associated glycoprotein (MAG). Ectopic expression of alpha chimaerin in cerebellar neurons results in resistance to MAG in regard to neurite outgrowth. These results suggest that up-regulated expression of chimaerin counteracts the activation of RhoA, which is a key molecule in transducing inhibitory signals in neurons.