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Nanotechnology ; 22(26): 265103, 2011 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-21576788

RESUMO

Our data demonstrate that multi-walled carbon nanotubes (MWCNTs) are internalized by macrophages, subsequently activating them to produce interleukin (IL)-12 (IL-12). This cytokine induced the proliferative response of T lymphocytes to a nonspecific mitogen and to ovalbumin (OVA). This increase in the proliferative response was accompanied by an increase in the expression of pro-inflammatory cytokines, such as interferon-gamma (IFNγ), tumor necrosis factor-alpha (TNFα) and IL-6, in mice inoculated with MWCNTs, whether or not they had been immunized with OVA. A decrease in the expression of transforming growth factor-beta (TGFß) was observed in the mice treated with MWCNTs, whereas the suppression of the expression of both TGFß and IL-10 was observed in mice that had been both treated and immunized. The activation of the T lymphocyte response by the pro-inflammatory cytokines leads to an increase in antibody production to OVA, suggesting the important immunostimulatory effect of carbon nanotubes.


Assuntos
Formação de Anticorpos/imunologia , Citocinas/metabolismo , Mediadores da Inflamação/metabolismo , Macrófagos/metabolismo , Nanotubos de Carbono/química , Linfócitos T/imunologia , Regulação para Cima/imunologia , Animais , Antígenos/imunologia , Linfócitos B/imunologia , Endocitose , Regulação da Expressão Gênica , Interleucina-12/genética , Interleucina-12/metabolismo , Ativação Linfocitária/imunologia , Ativação de Macrófagos/imunologia , Camundongos , Camundongos Endogâmicos C57BL , Nanotubos de Carbono/ultraestrutura , Ovalbumina/imunologia , Análise Espectral Raman
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