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Vet Res Commun ; 47(3): 1641-1651, 2023 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-37022654

RESUMO

Fungi are ubiquitous in the environment and part of the commensal microflora on the conjunctiva of equine eyes. North Queensland, being tropical, presents an ideal environment for fungi growth. When the cornea is injured, fungi can invade the corneal stroma, resulting in keratomycosis. The objectives of this study were to determine the fungal species specific to the eyes of horses in the Townsville region; to investigate the potential risk factors associated with the presence of fungi; and to test their susceptibility to antifungals to create an empirical guide for treatment. The eyes of forty ophthalmologically normal horses from James Cook University were sampled throughout the summer months of December 2017, January 2018, and January and February 2020. Cultured fungi were identified morphologically, and their identity confirmed by comparing partial 18sRNA DNA sequences with the NCBI nucleotide database. Minimum inhibitory concentration testing of common antifungal medications was performed. Sixty-one out of eighty conjunctival samples grew fungi, and 21 different fungi genera were isolated. The most common genera were Aspergillus (18%, 26/141), Curvularia (14%,20/141), Rhodotorula (12%,17/141) and Penicillium (12%,17/141). No significant association was found between age or environmental factors and fungal culture status. Most fungi were highly susceptible to voriconazole and ketoconazole but resistant to fluconazole and amphotericin B. This adds to the body of evidence on which species of fungi are present as normal ocular microflora of horses living in tropical regions of Australia, and an avenue for treating them.


Assuntos
Infecções Oculares Fúngicas , Doenças dos Cavalos , Cavalos , Animais , Antifúngicos/farmacologia , Queensland , Infecções Oculares Fúngicas/tratamento farmacológico , Infecções Oculares Fúngicas/veterinária , Infecções Oculares Fúngicas/microbiologia , Anfotericina B/uso terapêutico , Testes de Sensibilidade Microbiana/veterinária , Túnica Conjuntiva/microbiologia , Doenças dos Cavalos/tratamento farmacológico
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