Percutaneous Coronary Intervention as a Non-Surgical Treatment for Ischemic Mitral Regurgitation in Patients with Multi-Vessel Coronary Artery Disease.

BACKGROUND Multi-vessel coronary artery disease (MVD) represents a severe type of coronary artery disease (CAD). Ischemic mitral regurgitation (IMR) is a common mechanical complication in patients with CAD. This study aimed to retrospectively investigate the efficacy of percutaneous coronary intervention (PCI) on moderate/severe IMR in patients with MVD. MATERIAL AND METHODS Clinical data were collected from 15 patients who underwent successful treatment for MVD combined with moderate/severe IMR through the PCI procedure and achieved complete revascularization between January 2014 and December 2022. Cardiac structural and functional parameters were assessed through echocardiographic evaluations. Color flow recordings of MR jets were obtained through an enlarged view of the 4-chamber cut, and the diagnosis of MR was categorized into mild (<4 cm²), moderate (4-8 cm²), and severe (>8 cm²), based on the MR area. RESULTS The common features of the selected cases were advanced age, low body weight, and renal insufficiency. Cardiac echocardiography revealed an augmentation in the left atrial anteroposterior diameter and left ventricular internal diameter at end-systole after PCI, while the left ventricle internal diameter in diastole, left ventricular ejection fraction, and left ventricular fractional shortening were comparable to preoperative values. All patients had moderate/severe MR preoperatively, and MR improved at 1 month (2.73±0.69) and 12 months (2.26±0.58) after PCI. CONCLUSIONS In cases of MVD accompanied by moderate/severe IMR, undergoing PCI can spare certain elderly patients with low body weight and renal insufficiency from high-risk surgery, alleviating the severity of MR without undergoing mitral valve intervention.

Nitrogen doped magnetic porous carbon derived from starch of oatmeal for efficient activation peroxymonosulfate to degradation sulfadiazine.

Nitrogen doped magnetic porous carbon catalyst based on starch of oatmeal was obtained by mixing and pyrolysis process, and its catalytic activity of peroxymonosulfate activation for sulfadiazine degradation was evaluated. When ratio of oatmeal/urea/iron was 1: 2: 0.1, CN@Fe-10 had the best catalytic activity to degrade sulfadiazine. Around 97.8 % removal of 20 mg L-1 sulfadiazine was achieved under incorporating of 0.05 g L-1 catalyst and 0.20 g L-1 peroxymonosulfate. Good adaptability, stability and universality of CN@Fe-10 were verified under different conditions. Electron paramagnetic resonance and radical quenching test suggested that surface-bound reactive oxides species and singlet oxygen were the main reactive oxides species in this reaction. Electrochemical analysis indicated that CN@Fe-10 had a good electrical conductivity and electron transferred did occur among CN@Fe-10 surface, peroxymonosulfate and sulfadiazine. X-ray photoelectron spectroscopy suggested that Fe0, Fe3C, pyridine nitrogen and graphite nitrogen were the potential active sites for peroxymonosulfate activation. Therefore, the work provided a practical approach for recycling biomass.