RESUMO
CD64, the high-affinity receptor in the family of FCgamma receptors, is not expressed constitutively in polymorphonuclear leucocytes (PMN). CD64 is expressed by PMNs in the late stages of human immunodeficiency virus (HIV) infection in adults. We followed the expression of CD64 on PMNs in perinatally HIV-infected children during disease progression. Peripheral blood leucocytes (PBL) from 45 perinatally HIV-infected paediatric patients and 13 healthy age-matched controls were analysed using cytofluorimetry after reaction with a fluorophore-labelled monoclonal antibody (MoAb) to CD64. In parallel, we examined the expression of CD32, CD16, CD11b and the human neutrophil-specific BH2-Ag using fluorophore-labelled MoAbs. We found that up to 79.5% of the PMNs in children in class C3 express CD64. Most importantly, we observed a continuous and significant increase in the appearance of CD64+ PMNs as a function of CDC classification (P < 0.001) but no changes in the expression of CD32, CD16, CD11b and BH2-Ag. This suggests that following the expression of CD64 on PMNs can be useful in evaluating the progression of HIV infection in perinatally HIV-infected children.
Assuntos
Síndrome da Imunodeficiência Adquirida/etiologia , Síndrome da Imunodeficiência Adquirida/imunologia , Infecções por HIV/imunologia , Infecções por HIV/transmissão , Neutrófilos/imunologia , Receptores de IgG/metabolismo , Adolescente , Adulto , Estudos de Casos e Controles , Criança , Pré-Escolar , Feminino , Humanos , Sistema Imunitário/crescimento & desenvolvimento , Recém-Nascido , Transmissão Vertical de Doenças Infecciosas , Antígeno de Macrófago 1/metabolismo , Masculino , GravidezRESUMO
A 14-year-old girl with perinatally acquired human immunodeficiency virus infection had fatal intravascular hemolysis after intravenous administration of ceftriaxone. Laboratory studies confirmed the presence of an antibody against ceftriaxone in the serum and on the patient's red blood cells. No evidence of sepsis, glucose-6-phosphate dehydrogenase deficiency or anaphylaxis was found.
Assuntos
Infecções Oportunistas Relacionadas com a AIDS/tratamento farmacológico , Anemia Hemolítica/induzido quimicamente , Ceftriaxona/efeitos adversos , Cefalosporinas/efeitos adversos , Infecções Oportunistas Relacionadas com a AIDS/imunologia , Adolescente , Anemia Hemolítica/imunologia , Anticorpos , Ceftriaxona/imunologia , Cefalosporinas/imunologia , Evolução Fatal , Feminino , Infecções por HIV/complicações , Infecções por HIV/imunologia , Hemólise/efeitos dos fármacos , HumanosRESUMO
The authors report an 18-year-old girl with HIV infection who developed new-onset insulin-dependent diabetes mellitus (IDDM) in association with anemia. IDDM among patients with HIV infection has been infrequently reported and suggested to be caused by different etiologies. Susceptibility to autoimmune diseases, such as IDDM, has been associated functionally with two members of a newly described multigene family called PERB11. In this patient, the progression of hyperglycemia associated with a rapid increase in insulin requirement is suggestive of insulin resistance.
