[Randomised study to evaluate the chronotolerance of a combination infusional chemotherapy with 5-fluorouracil, folinic acid and carboplatin in non small cell lung cancer (NSCLC) patients]. / Etude randomisée évaluant la chronotolérance d'une association de 5-fluorouracile, acide folinique et carboplatine chez des patients porteurs d'un cancer pulmonaire non à petites cellules (CPNPC).

An infusional ambulatory chronotherapy with 5-FU, folinic acid (FOL) and carboplatin was administered to 45 advanced NSCLC patients. The patients were randomised into 3 groups varying according to the time of administration peak of drugs (reference hours: 4 a.m. for 5 FU (and FOL); 4 p.m. for carboplatin; +/-8 h). The reference schedule appeared best tolerated (regarding hematology and mucositis). This study has prospectively validated the chronotolerance concepts of this complex combination chemotherapy.

[Evaluation of rest-activity rhythms in advanced non-small-cell lung cancer (NSCLC) patients. Importance of corticotherapy?]. / Evaluation des rythmes d'activité et de repos chez des patients porteurs d'un cancer pulmonaire non à petites cellules (CPNPC) de stade avancé. Rôle de la corticothérapie?

The circadian structure (i.e. rest-activity cycle) was evaluated by actometry in a group of 25 advanced NSCLC patients. A better circadian profile was observed in the 6 patients treated with corticosteroïds. However those patients had also a shortened survival.