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1.
Sci Rep ; 14(1): 16424, 2024 Jul 16.
Artigo em Inglês | MEDLINE | ID: mdl-39013935

RESUMO

Lately, children's daily consumption of some products, such as cereals and candies, has been rising, which provides a compelling rationale for determining any metallic substances that may be present. Monitoring the concentration of certain metals, like nickel, in these products is necessary due to medical issues in humans when consumed regularly. So, in this work, a novel and highly selective carbon paste as a Ni(II) ion-selective sensor was prepared and investigated using ceramic magnesium aluminum spinel nanoparticles as the ionophore and tritolyl phosphate (TOCP) as a plasticizer. A modified co-precipitation method was used to synthesize the spinel nanoparticles. X-ray diffraction, scanning electron microscope with EDAX, transmission electron microscope, and BET surface area were used to determine the phase composition, microstructure, pores size, particle size, and surface area of the synthesized nanoparticles. The spinel nanoparticle was found to have a nano crystallite size with a cubic crystal system, a particle size ranging from 17.2 to 51.52 nm, mesoporous nature (average pore size = 8.72 nm), and a large surface area (61.75 m2/g). The composition ratio of graphite carbon as a base: TOCP as binder: spinal as ionophore was 67.3:30.0:2.7 (wt%) based on potentiometric detections over concentrations from 5.0 × 10-8 to 1.0 × 10-2 mol L-1 with LOD of 5.0 × 10-8 mol L-1. A measurement of 29.22 ± 0.12 mV decade-1 over pH 2.0-7.0 was made for the Nernstian slope. This sensor demonstrated good repeatability over nine weeks and a rapid response of 8 s. A good selectivity was shown for Ni(II) ions across many interferents, tri-, di-, and monovalent cations. The Ni(II) content in spiked real samples, including cocaine, sweets, coca, chocolate, carbonated drinks, cereals, and packages, were measured. The results obtained indicated no significant difference between the proposed potentiometric method and the officially reported ICP method according to the F- and t-test data. In addition to utilizing ANOVA statistical analysis, validation procedures have been implemented, and the results exceed the ICP-MS methodology.


Assuntos
Níquel , Níquel/análise , Níquel/química , Humanos , Criança , Óxido de Magnésio/química , Técnicas Eletroquímicas/métodos , Óxido de Alumínio/química , Nanopartículas/química , Magnésio/química , Magnésio/análise , Íons/análise , Difração de Raios X , Ionóforos/química
2.
J Anim Physiol Anim Nutr (Berl) ; 108(3): 839-853, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38323934

RESUMO

This experiment was designed to investigate the impact of curcumin-olive oil nanocomposite (CONC) supplementation on uteroplacental hemodynamics and ultrasonographic measurements as well as maternal oxidative status in midgestating goats. Twelve synchronized pregnant goats (85.58 ± 1.08 days of gestation; mean ± SD) were uniformly assigned to two groups (n = 6/group); the first group received daily oral supplementation of CONC (3 mg/kg body weight; nanocurcumin [NC] group) for 32 days, and the second group was offered physiological saline (control) following the NC group timeline. The goats of both groups were examined at 3-day intervals for middle uterine (MUA) and umbilical (UMA) arteries hemodynamics (pulsatility index [PI], resistive index [RI], systole/diastole [S/D] and blood flow rate [BFR]) and diameters, uteroplacental thickness (UPT), placentomes' diameter (PD) and echogenicity, steroid hormones (progesterone and estradiol 17ß), oxidative biomarkers (total antioxidant capacity [TAC], catalase [CAT], malondialdehyde [MDA]), nitric oxide (NO) and blood cells DNA integrity. The UPT (p = 0.012) and PD (p = 0.021) values were higher in the NC group than in their counterparts' control group (D11-32). There were increases in diameter (p = 0.021 and p = 0.012) and decreases (p = 0.021, p = 0.016 and p = 0.041 [MUA]; p = 0.015, p = 0.023 and p = 0.011 [UMA] respectively) in Doppler indices (PI, RI and S/D) of the MUA and UMA in the NC group compared to the control group (D14-32). On D20-32 (MUA) and D14-32 (UMA), the NC goats had higher BFR than the control group (p = 0.021, 0.018 respectively). The means of blood cells with fragmented DNA were lower (p = 0.022) in the NC group than in the control group on Days 8 and 21 postsupplementation. There were increases in CAT and NO (D20-32; p = 0.022 and p = 0.004 respectively), and TAC (D17-32; p = 0.007) levels in the NC goats compared to the control ones. The NC group had lower (p = 0.029) concentrations of MDA than the control group on Day 20 postsupplementation onward. In conclusion, oral supplementation of CONC improved uteroplacental blood flow and the antioxidant capacity of midgestating goats.


Assuntos
Antioxidantes , Curcumina , Suplementos Nutricionais , Cabras , Placenta , Útero , Animais , Feminino , Gravidez , Ração Animal/análise , Fenômenos Fisiológicos da Nutrição Animal , Antioxidantes/farmacologia , Antioxidantes/metabolismo , Curcumina/farmacologia , Curcumina/administração & dosagem , Dieta/veterinária , Cabras/fisiologia , Nanocompostos/química , Placenta/efeitos dos fármacos , Circulação Placentária/efeitos dos fármacos , Útero/efeitos dos fármacos , Útero/irrigação sanguínea
3.
Discov Nano ; 19(1): 12, 2024 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-38224391

RESUMO

A comprehensive investigation into the green synthesis of metal oxide nanoparticles (NPs) has garnered significant attention due to its commendable reliability, sustainability, and environmentally friendly attributes. Green synthesis methods play a crucial role in mitigating the adverse effects associated with conventional approaches employed for nanostructure preparation. This research endeavors to examine the impact of ginger plant extract-assisted green synthesis of metal oxides NPs on the serum ferritin levels of anemic diabetic patients in vitro, focusing specifically on α-Fe2O3 and ZnO NPs. Sixty diabetic volunteers with anemia (35-50 years) and thirty healthy volunteers were enrolled as controls. The assessment was conducted using the VIDAS Ferritin (FER) assay. Photoluminescence (PL) spectroscopy measurements were performed to elucidate the intrinsic and extrinsic transitions of these NPs, affirming the successful formation of α-structured iron oxide. Density functional theory (DFT) calculations were carried out at the B3LYP/6-311++G(d,2p) level of theory to investigate the geometry optimization and molecular electrostatic potential maps of the NPs. Furthermore, TD-DFT calculations were employed to explore their frontier molecular orbitals and various quantum chemical parameters. The binding affinity and interaction types of ZnO and α-Fe2O3 NPs to the active site of the human H-Chain Ferritin (PDB ID: 2FHA) target were determined with the help of molecular docking. Results unveiled the crystalline structure of ZnO and the α-structure of α-Fe2O3. Analysis of the frontier molecular orbitals and dipole moment values demonstrated that ZnO (total dipole moment (D) = 5.80 µ) exhibited superior chemical reactivity, biological activity, and stronger molecular interactions with diverse force fields compared to α-Fe2O3 (D = 2.65 µ). Molecular docking of the metal oxides NPs with human H-chain ferritin provided evidence of robust hydrogen bond interactions and metal-acceptor bonds between the metal oxides and the target protein. This finding could have a great impact on using metal oxides NPs-ferritin as a therapeutic protein, however, further studies on their toxicity are required.

4.
Molecules ; 28(24)2023 Dec 18.
Artigo em Inglês | MEDLINE | ID: mdl-38138637

RESUMO

The metal-organic framework (MOF) is a class of materials that exhibits a notable capacity for electron transfer. This unique framework design offers potential applications in various fields, including catalysis, gas storage, and sensing. Herein, we focused on a specific type of MOF called Ti-MOF. To enhance its properties and functionality, the composite material was prepared by incorporating graphitic carbon nitride (g-C3N4) into the Ti-MOF structure. This composite, known as g-C3N4@Ti-MOF, was selected as the active material for ion detection, specifically targeting calcium ions (Ca2+). To gain a comprehensive understanding of the structural and chemical properties of the g-C3N4@Ti-MOF composite, several analytical techniques were employed to characterize the prepared g-C3N4@Ti-MOF composite, including X-ray diffraction (XRD), SEM-EDX, and FT-IR. For comparison, different pastes were prepared by mixing Ti-MOF or g-C3N4@Ti-MOF, graphite, and o-NPOE as a plasticizer. The divalent Nernstian responses of the two best electrodes, I and II, were 28.15 ± 0.47 and 29.80 ± 0.66 mV decade-1, respectively, with concentration ranges of 1 µM-1 mM and 0.1 µM-1 mM with a content 1.0 mg Ti-MOF: 250 mg graphite: 0.1 mL o-NPOE and 0.5 mg g-C3N4@Ti-MOF: 250 mg graphite: 0.1 mL o-NPOE, respectively. The electrodes showed high sensitivity and selectivity for Ca2+ ions over different species. The suggested electrodes have been successfully employed for Ca2+ ion measurement in various real samples with excellent precision (RSD = 0.74-1.30%) and accuracy (recovery = 98.5-100.2%), and they exhibited good agreement with the HPLC.

5.
Sci Rep ; 13(1): 19391, 2023 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-37938602

RESUMO

In this study, metal oxides nanoparticles heterogeneous photocatalysts prepared by coprecipitation and ultrasonic techniques were used for diesel desulfurization. They were characterized by scanning electron microscope, powder X-ray diffraction, energy dispersive analysis, diffused reflectance spectra, photoluminescence analysis and BET surface area. The surface area of catalyst B is larger than catalyst A confirming its higher reactivity. X-ray reflectance spectroscopy was used to analyze the sulfur contents in feed. Thiophene was used as a model fuel to evaluate the photocatalytic activity of catalysts A and B. Using the Scherrer equation, sharp and intense signals suggesting their higher degrees of crystallinity, with average crystal sizes for ZnO, Bi2O3, catalysts A and B, respectively; of 18, 14.3, 29.7, and 23.8 nm. The operational parameters of the desulfurization process were optimized and have been studied and the maximum sulfur removal was achieved via a further solvent extraction step. A diesel fuel with a 24 and 19 ppm sulfur content and hence a total sulfur removal of 94.6% and 95.7% was acquired for catalysts A and B, respectively (sulfur compounds concentration in diesel fuel feedstock was 450 ppm). These findings demonstrated that photocatalysts A and B are good and effective catalysts for desulfurization of diesel fuel.

6.
Sci Rep ; 13(1): 19621, 2023 Nov 10.
Artigo em Inglês | MEDLINE | ID: mdl-37949908

RESUMO

Methylene blue (MB) dye is considered a well-known dye in many industries and the low concentration of MB is considered very polluted for all environment if it discharged without any treatment. For that reason, many researchers used advanced technologies for removing MB such as the electrochemical methods that considered very simple and give rapid response. Considering these aspects, a novel quartz crystal microbalance nanosensors based on different concentrations of PVC@SiO2 were designed for real-time adsorption of MB dye in the aqueous streams at different pHs and different temperatures. The characterization results of PVC@SiO2 showed that the PVC@SiO2 have synthesized in spherical shape. The performance of the designed QCM-Based PVC@SiO2 nanosensors were examined by the QCM technique. The sensitivity of designed nanosensors was evaluated at constant concentration of MB (10 mg/L) at different pHs (2, 7 and 11) and temperatures (20 °C, 25 °C, and 30 °C). From the experimental, the best concentration of PVC@SiO2 was 3% for adsorbed 9.99 mg of cationic methylene blue at pH 11 and temperature 20 °C in only 5.6 min.

7.
Sci Rep ; 13(1): 12531, 2023 Aug 02.
Artigo em Inglês | MEDLINE | ID: mdl-37532800

RESUMO

Metal organic frameworks (MOFs) are a class of porous materials characterized by robust linkages between organic ligands and metal ions. Metal-organic frameworks (MOFs) exhibit significant characteristics such as high porosity, extensive surface area, and exceptional chemical stability, provided the constituent components are meticulously selected. A metal-organic framework (MOF) containing lead and ligands derived from 4-aminobenzoic acid and 2-carboxybenzaldehyde has been synthesized using the sonochemical methodology. The crystals produced were subjected to various analytical techniques such as Fourier-transform infrared spectroscopy (FT-IR), Powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX), Brunauer-Emmett-Teller (BET), and thermal analysis. The BET analysis yielded results indicating a surface area was found to be 1304.27 m2 g-1. The total pore volume was estimated as 2.13 cm3 g-1 with an average pore size of 4.61 nm., rendering them highly advantageous for a diverse range of practical applications. The activity of the modified Pb-MOF electrode was employed toward water-splitting applications. The electrode reached the current density of 50 mA cm-2 at an overpotential of - 0.6 V (vs. RHE) for hydrogen evolution, and 50 mA cm-2 at an overpotential of 1.7 V (vs. RHE) for oxygen evolution.

8.
RSC Adv ; 13(16): 11201-11214, 2023 Apr 03.
Artigo em Inglês | MEDLINE | ID: mdl-37056976

RESUMO

Tetragonal zirconia (t-ZrO2) nanoparticles (ionophore) are used in newly designed and improved ion selective electrodes for chromium ion detection as an alternative, low-cost, high-precision, and selectivity method. Tetragonal zirconia nanoparticles were synthesized using a modified co-precipitation technique and calcined at 1000 °C for an hour. The phase composition, surface area, microstructure, pore size and particle size of synthesized t-ZrO2 nanoparticles were examined using the X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), transmission electron microscope (TEM) and scanning electron microscopy (SEM) attached with an EDAX unit, respectively. Results from XRD showed that the t-zirconia was synthesized and have nanocrystallites size about 20.2 nm. The nano size of t-ZrO2 was confirmed by the SEM and TEM (the particle size between 26.48 and 40.4 nm), the mesoporous character (average pore size about 4.868 nm) and large surface area (76.2802 m2 g-1) was confirmed by BET analysis. The paste composition with 67.3 : 30.5 : 2.7 (wt%) graphite, t-ZrO2, and TCP, respectively, exhibited the best results. With a detection limit of 1.0 × 10-8 mol L-1, the electrode displayed a good Nernstian slope of 19.50 ± 0.10 mV decade-1 over the concentration range from 1.0 × 10-2 to 1.0 × 10-8 mol L-1 of Cr(iii) ions. The built-in sensor displayed a quick response time (7 s), was highly thermally stable in the range of 10 to 60 °C without departing from Nernstian behaviour and could be used for about 60 days in the pH range of 2.0 to 6.0. The electrode demonstrated excellent selectivity for the Cr(iii) ion towards a variety of metal ions. For chromium ion determination, numerous spiked real samples, including honey, water, tea, coffee, milk, cheese, and cosmetics, were used. Validation methods were used, and the results showed that there is no significant difference between the two methods (ICP and ISE) at a 95% confidence level. In several real water samples, the estimated limits of detection, limits of quantification, percent recovery, standard deviation, and relative standard deviation showed the effectiveness of the proposed electrode in the potentiometric detection of Cr(iii) ions.

9.
Sci Rep ; 13(1): 4431, 2023 Mar 17.
Artigo em Inglês | MEDLINE | ID: mdl-36932149

RESUMO

An important industrial process that often occurs on the surface of a heterogeneous catalyst using thermochemical or photochemical could help in the oxidation of methanol-based wastewater to formaldehyde. Titania-based photocatalysts have drawn a lot of interest from scientists because they are a reliable and affordable catalyst material for photocatalytic oxidation processes in the presence of light energy. In this study, a straight-forward hydrothermal method for producing n-TiO2@α-Fe2O3 composite photocatalysts and hematite (α-Fe2O3) nanocubes has been done. By adjusting the ratio of n-TiO2 in the prepared composite photocatalysts, the enhancing influence of the nitrogen-doped titania on the photocatalytic characteristics of the prepared materials was investigated. The prepared materials were thoroughly characterized using common physiochemical methods, such as transmission electron microscope (TEM), scanning electron microscope (SEM), X-ray diffraction (XRD), energy dispersive X-ray (EDX), X-ray photoelectrons spectroscopy (XPS), physisorption (BET), and others, in order to learn more about the structure The results obtained showed that nitrogen-doped titania outperforms non-doped titania for methanol photooxidation. The addition of nitrogen-doped titania to their surfaces resulted in an even greater improvement in the photooxidation rates of the methanol coupled with hematite. The photooxidation of methanol in the aqueous solution to simulate its concentration in the wastewater has been occurred. After 3 h, the four weight percent of n-TiO2@α-Fe2O3 photocatalyst showed the highest rate of HCHO production.

10.
Materials (Basel) ; 16(3)2023 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-36769903

RESUMO

A new heterocyclic azo dye ligand (L) was synthesized by the combination of 4-amino antipyrine with 4-aminophenol. The new Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) complexes were synthesized in excellent yields. The metal chelate structures were elucidated using elemental analyses, FT-IR, 1H-NMR, mass, magnetic moment, diffused reflectance spectral and thermal analysis (TG-DTG), and molar conductivity measurement. According to the FT-IR study, the azo dye ligand exhibited neutral tri-dentate behavior, binding to the metal ions with the azo N, carbonyl O, and protonated phenolic OH. The 1H-NMR spectral study of the Zn(II) complex supported the coordination of the zo dye ligand without proton displacement of the phenolic OH. Diffused reflectance and magnetic moment studies revealed the octahedral geometry of the complexes, as well as their good electrolytic nature, excepting the Zn(II) and Cd(II) complexes, which were nonelectrolytes, as deduced from the molar conductivity study. The theoretical calculations of optimized HOMO-LUMO energies, geometrical parameters, electronic spectra, natural atomic charges, 3D-plots of MEP, and vibrational wavenumbers were computed and elucidated using LANL2DZ and 6-311G (d, p) basis sets of density functional theory (DFT) with the approach of B3LYP DFT and TD-DFT methods. The ligand and complexes have been assayed for their antimicrobial activity and compared with the standard drugs. Most of the complexes have manifested excellent antimicrobial activity against various microbial strains. A molecular docking investigation was also performed, to acquire more information about the binding mode and energy of the ligand and its metal complexes to the Escherichia coli receptor using molecular docking. Altogether, the newly created ligand and complexes showed positive antibacterial effects and are worth future study.

11.
J Water Health ; 21(1): 1-8, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36705493

RESUMO

The widespread use of chlorine pre-oxidation in water purification has been limited in several countries owing to the production of carcinogenic byproducts when combined with naturally occurring organic matter. This study investigates the efficient use of potassium permanganate (KMnO4) pretreatment and coagulation enhancement as particle size and molecular weight distribution controlling parameters. KMnO4 pretreatment significantly reduced the apparent molecular weight of humic acid due to KMnO4 reduction and the continuous generation of manganese dioxide (MnO2) formed in situ under neutral and alkaline conditions. The MnO2 formed in situ had adsorption characteristics that enabled it to form large and stable flocs with the hydrolysis products of aluminum sulfate. However, under acidic conditions, KMnO4 pretreatment exhibited strong oxidation characteristics due to Mn(VII) reduction to Mn(II), and the mean particle floc size was the same as without KMnO4 pretreatment. Overall, KMnO4 pretreatment is a useful alternative strategy for traditional pre-oxidation using chlorine and a good coagulant enhancement agent in neutral and basic media.


Assuntos
Permanganato de Potássio , Purificação da Água , Compostos de Manganês , Óxidos , Desinfecção , Cloro , Oxirredução
12.
Materials (Basel) ; 15(22)2022 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-36431696

RESUMO

Silica nanoparticles (SiO2 NPs) are one of the most well-studied inorganic nanoparticles for many applications. They offer the advantages of tunable size, biocompatibility, porous structure, and larger surface area. Thus, in this study, a high yield of SiO2 NPs was produced via the chemical treatment of rice husk ash by the sol-gel method. Characteristics of the prepared SiO2 NPs were validated using different characterization techniques. Accordingly, the phase, chemical composition, morphological, and spectroscopic properties of the prepared sample were studied. The average particle size of the SiO2 NPs was found to be approximately 60-80 nm and the surface area was 78.52 m²/g. The prepared SiO2 NPs were examined as photocatalysts for the degradation of methyl orange (MO) dye under UV irradiation. It was found that the intensity of the characteristic absorption band of MO decreased gradually with exposure time increasing, which means the successful photodegradation of MO by SiO2 NPs. Moreover, the antibacterial activity of obtained SiO2 NPs was investigated by counting the coliform bacteria in the surface water using the most probable number (MPN) index method. The results revealed that the MPN of coliform bacteria untreated and treated by SiO2 NPs was estimated to be 170 CFU/100 mL and 10 CFU/100 mL, respectively, resulting in bacterial growth inhibition of 94.12%.

13.
ACS Omega ; 7(43): 38347-38360, 2022 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-36340163

RESUMO

In this study, graphene oxide (GO) was functionalized with 3,5-diaminobenzoic acid (DABA) by a one-step method to produce functionalized graphene oxide (FGO). FGO is a new type of absorbent crystalline substance that has a high surface area and a large porosity site as well as a large number of dentate functional groups which lead to enhanced adsorption performance for heavy metal ions. The adsorption efficiency of FGO for Pb+2 and Al+3 metal ions was extra satisfactory when compared with GO due to the ease of design and the homogeneous structure of FGO. The structure of synthesized GO and FGO was confirmed by different techniques such as FTIR, XRD, TGA, BET nitrogen adsorption-desorption methods, and TEM analyses. The mass of utilized adsorbents, the pH of the medium, the concentration of ionic species in the medium, temperature, and process time were all investigated as variables in the adsorbent procedure. The experimental data recorded that the maximum adsorption efficiency of the 0.5 g/L FGO composite was 99.7 and 99.8% for Pb+2 and Al+3 metal ions, respectively, while in the case of using GO, the maximum adsorption efficiency was 92.6 and 91.9% at ambient temperature in a semineutral medium at pH 6 after 4 h. The adsorption results were in good conformity with the Freundlich model and pseudo-second-order kinetics for Pb+2 and Al+3 metal ions. Also, the reusability study indicates that FGO can be used repeatedly at least for five cycles with a slight significant loss in its efficiency.

14.
Materials (Basel) ; 15(14)2022 Jul 12.
Artigo em Inglês | MEDLINE | ID: mdl-35888309

RESUMO

Some novel imine metal chelates with Cr3+, Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Zn2+, and Cd2+ cations were produced from 2-acetylferrocene and 3-aminophenol. The new acetylferrocene azomethine ligand ((Z)-cyclopenta-1,3-dien-1-yl(2-(1-((3-hydroxyphenyl)imino)ethyl)cyclopenta-2,4-dien-1-yl)iron) and its metal ion chelates were constructed and elucidated using FT-IR, UV/Vis, 1HNMR, DTA/TGA, CHNClM studies, mass spectrometry and SEM analysis. According to the TGA/DTG investigation, the ferrocene moiety spontaneously disintegrates to liberate FeO. The morphology of the free acetylferrocene azomethine via SEM analysis was net-shaped with a size of 64.73 nm, which differed in Cd(II) complex to be a spongy shape with a size of 42.43 nm. The quantum chemical features of the azomethine ligand (HL) were computed, and its electronic and molecular structure was refined theoretically. The investigated acetylferrocene imine ligand behaves as bidinetate ligand towards the cations under study to form octahedral geometries in case of all complexes except in case of Zn2+ is tetrahedral. Various microorganisms were used to investigate the anti-pathogenic effects of the free acetylferrocene azomethine ligand and its metal chelates. Moreover, the prepared ligand and its metal complexes were tested for anticancer activity utilizing four different concentrations against the human breast cancer cell line (MCF7) and the normal melanocyte cell line (HBF4). Furthermore, the binding of 3-aminophenol, 2-acetylferrocene, HL, Mn2+, Cu2+, and Cd2+ metal chelates to the receptor of breast cancer mutant oxidoreductase was discovered using molecular docking (PDB ID: 3HB5).

15.
Materials (Basel) ; 15(10)2022 May 20.
Artigo em Inglês | MEDLINE | ID: mdl-35629702

RESUMO

The newly synthesized organometallic acetyl ferrocene imine ligand (HL) was obtained by the direct combination of 2-acetyl ferrocene with 2-aminothiophenol. The electronic and molecular structure of acetyl ferrocene imine ligand (HL) was refined theoretically and the chemical quantum factors were computed. Complexes of the acetyl ferrocene imine ligand with metal(II)/(III) ions (Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II)) were fabricated. They were inspected by thermal (DTG/TG), spectroscopic techniques (FT-IR, 1H NMR, mass, UV-Vis), molar conductivity, and CHNClM to explicate their structures. Studies using scanning electron microscope (SEM) were conducted on the free acetyl ferrocene imine ligand and its Cd(II) chelate to confirm their nano-structure. To collect an idea about the effect of metal ions on anti-pathogenic properties upon chelation, the newly synthesized acetyl ferrocene imine ligand and some of its metal chelates were tested against a variety of microorganisms, including Bacillus subtilis, Staphylococcus aureus, Salmonella typhimurium, Escherichia coli, Aspergillus fumigatus, and Candida albicans. The ligand and its metal chelate were tested for cytotoxic activity in human cancer (MCF-7 cell viability) and human melanocyte cell line HBF4. It was discovered that the Cd(II) chelate had the lowest IC50 of the three and thus had the prior activity. Molecular docking was utilized to investigate the interaction of acetyl ferrocene imine ligand (HL) with the receptors of the vascular endothelial growth factor receptor VEGFR (PDB ID: 1Y6a), human Topo IIA-bound G-segment DNA crystal structure (PDB ID: 2RGR), and Escherichia coli crystal structure (PDB ID: 3T88).

16.
Water Environ Res ; 94(4): e10713, 2022 Mar 27.
Artigo em Inglês | MEDLINE | ID: mdl-35470523

RESUMO

Removal of selenite (Se (IV)) from wastewater is vital due to its more toxic and mobile properties. In this study, a novel dendritic silver-dendrites@ copper with hierarchical side-branches were synthesized through a two-pot rapid, facile, and green precipitation route. Characterization of the dendrites by transmission electron microscope (TEM), scanning electron microscope (SEM), dynamic light scattering (DLS), and X-ray diffraction spectroscopy (XRD) confirmed the proper preparation of dendritic AgCu nanostructure. Significantly, the Ag@Cu nanostructure has high specific surface area (150 m2 /g) and excellent adsorption activity toward selenite. The adsorption rate of Se (IV) on the dendritic AgCu reaches 94% within 60 min under normal adsorption procedures. Both adsorption kinetics and isotherms have been described well by the pesudo-second order model and Langmuir model, respectively. The noticeable high adsorption capabilities can mainly accredit to the effect of the hierarchical side-branched structure. Therefore, the dendritic AgCu nanostructure has a room of treating heavy metals-contaminated industrial wastewater streams. PRACTITIONER POINTS: Silver-dendrites@ copper with hierarchical side-branches were synthesized through a rapid and green precipitation route using copper nanoparticles. The prepared nanostructure was applied for Se (IV) adsorption at varying operational conditions (contact time, pH, and dose). High adsorption capacity for Se (IV) up to 173.1 mg/g was achieved using the prepared nanoparticles applying Langmuir isotherm model.

18.
Spectrochim Acta A Mol Biomol Spectrosc ; 272: 120971, 2022 May 05.
Artigo em Inglês | MEDLINE | ID: mdl-35152095

RESUMO

Two new water-soluble thiadiazole compounds are prepared and characterized with various techniques. These compounds, 5-amino-1,3,4-thiadiazole hydrochloride (1) and 5-amino-3-(N-propane-2-imine)-1,3,4-thiadiazole chloride salt (2) were synthesized via Mannich reaction, and characterized by microelemental analysis, and some spectroscopic means (FTIR, UV-Vis, 1H NMR, 13C NMR and mass), in addition to single-crystal X-ray diffraction for compound 2. DFT calculations were conducted to study their geometry optimization, vibrational spectra, MEP maps, and NBO analysis. In addition, TD-DFT calculations were performed to study their absorption spectra. The prepared compounds were tested against Jack beans urease enzyme (in vitro) to indicate their antiureolytic activity potency. The activity of the enzyme was measured under optimal conditions, before and after mixing with the prepared organic compounds. The results showed that both compounds have potentially inhibited the enzyme activity with respect to their IC50 values: 13.76 µM ± 0.15 for 1, and 18.81 µM ± 0.18 for 2. These values are even lower than that of thiourea (21.40 ± 0.21 µM) as a standard inhibitor. The inhibition activity of urease enzyme was confirmed by a Lineweaver-Burk plot. According to the kinetic parameters obtained from the Lineweaver-Burk plot, the inhibition of urease enzyme by compounds 1 and 2 seems to be non-competitive. Molecular docking studies of the prepared compounds 1 and 2 were performed in order to interpret the obtained biological results and to investigate their interactions with the urease enzyme active site. These studies reveal that compounds 1 and 2 are good candidates as inhibitors for urease enzyme. Moreover, compound 1 exhibits a higher promising inhibition activity.


Assuntos
Tiadiazóis , Inibidores Enzimáticos/química , Inibidores Enzimáticos/farmacologia , Simulação de Acoplamento Molecular , Relação Estrutura-Atividade , Tiadiazóis/química , Tiadiazóis/farmacologia , Urease , Água
19.
J AOAC Int ; 105(3): 727-738, 2022 Apr 27.
Artigo em Inglês | MEDLINE | ID: mdl-34935954

RESUMO

BACKGROUND: Many analytical techniques, such as X-ray fluorescence spectrometry, inductively coupled plasma-atomic emission spectrometry, and even traditional spectroscopic and fluorimetric methods, are used for the measurement of Cr(III) ions. These methods are sophisticated and very expensive, so the cheapest and low-cost ion selective electrodes were used. OBJECTIVE: The quantification of Cr(III) ions in various samples of petroleum water using ion selective electrodes was suggested. Nano chromium modified carbon paste sensor (MCPE) and nano chromium modified screen printed sensor (MSPE) based on Schiff base Cr(III) complex are developed. METHOD: The developed nano Cr(III) Schiff base chelate was characterized using elemental, spectroscopic, and thermal analysis techniques. The proposed nano Cr(III) has good properties for antibacterial and antifungal activity. The modified carbon paste and screen-printed sensors were fabricated for determination of Cr(III) ion. RESULTS: The proposed MCPE (sensor I) and MSPE (sensor II) obeys Nernstian equation upon incorporating nano Cr(III) ionophore in the paste at 25°C with a trivalent cationic slope of 18.8 ± 0.2 and 20.0 ± 0.4 mV/decade. They have showed fast response time around 8 and 5 s, and they may be used for at least 98 and 240 days without significant changes in MCPE and MSPE potential, respectively. The sensors I and II showed good selectivity for Cr(III) ion toward a wide variety of metal ions or anions as confirmed by potentiometric selectivity coefficients values. The detection and quantification limits were defined alongside the other process validation parameters. The results have been compared well to those obtained by atomic absorption spectrometry (AAS), and the data of F- and t-test indicated no significant difference between the proposed and AAS methods. CONCLUSIONS: These sensors have been used to determine Cr(III) ions in genuine spiked different petroleum well water samples with satisfactory percentage recoveries, low standard, and relative standard deviation values using direct potentiometric and standard addition methods. The proposed method of producing nano Cr(III) complex as a sensor material possesses the distinct advantages of being simple, easily reproducible, appropriate for operation, and highly selective and sensitive. HIGHLIGHTS: Modified carbon paste and screen-printed electrodes were fabricated based on nano Cr(III) complex as ionophore. The electrodes follow Nernstian behavior, and they optimized according to IUPAC recommendation. They showed a high selectivity for Cr(III) ion over many bi- or trivalent metal ions and anions. The results obtained compared well with those obtained using AAS. They successfully applied for determination of Cr(III) in petroleum water samples.


Assuntos
Cromo , Petróleo , Carbono/química , Cátions , Cromo/análise , Concentração de Íons de Hidrogênio , Eletrodos Seletivos de Íons , Ionóforos , Bases de Schiff , Água/química
20.
Materials (Basel) ; 16(1)2022 Dec 22.
Artigo em Inglês | MEDLINE | ID: mdl-36614421

RESUMO

Through the condensation of isatin (indoline-2, 3-dione) and aniline in a 1:1 ratio, a Schiff base ligand was synthesized and characterized via (1H-NMR, mass, IR, UV-Vis) spectra. Elemental analyses, spectroscopy (1H-NMR, mass, UV-Vis), magnetic susceptibility, molar conductivity, mass spectra, scanning electron microscope (SEM), and thermal analysis have all been used to characterize a series of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) metal complexes derived from the titled ligand. The metal-to-ligand ratio is 1:1, according to the analytical data. The Schiff base ligand displayed bidentate behavior with NO coordination sites when it bonded to metal ions, as seen by the IR spectra. The magnetic moment measurement and UV-Vis spectral investigation showed the octahedral geometry of the Cr(III), Fe(III), Co(II), Ni(II), and Zn(II) complexes, whereas they suggested the tetrahedral geometry of the Mn(II), Cu(II), and Cd(II) complexes. The thermal analysis study confirmed the presence of both hydrated and coordinated water molecules in all the compounds, except for the Mn(II) complex, and showed that the complexes decomposed in three or five decomposition steps leaving the corresponding metal oxide as a residue. The ligand and its metal complexes' antibacterial efficacy were evaluated. The findings showed that the metal complexes had stronger antibacterial properties than the ligand alone. The ligand and its metal complexes' anticancer properties were also investigated. A DFT investigation is also reported to gather information regarding the electronic features of the ligand and its metal complexes. Finally, drug-likeness and ADME characteristics were also calculated as parameters.

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