Untreated obstructive sleep apnea is associated with increased hospitalization from influenza infection.

STUDY OBJECTIVES: There is evidence that sleep deprivation or diseases such as obstructive sleep apnea (OSA) that lead to sleep disruption may adversely impact immune system functioning. We hypothesized that individuals who have OSA who did not use continuous positive airway pressure (CPAP) would have higher rates of hospitalization and complications from influenza infection than patients with OSA who were adherent to treatment. METHODS: Medical records of patients at Dartmouth-Hitchcock Medical Center in Lebanon, New Hampshire who had both OSA and a new, laboratory-confirmed influenza infection between 2016 and 2018 were reviewed for results of polysomnography, CPAP usage, influenza vaccination records, confirmation of influenza infection, and influenza-related hospitalizations and complications. RESULTS: Compared to the patients who were adherent to CPAP, patients who were either conservatively treated without CPAP or who were nonadherent to CPAP therapy had higher odds of hospitalization from influenza infections (odds ratio = 4.7, 95% confidence interval 1.3 to 19.5, P = .01) but no higher odds of complications from influenza. The patients who had untreated sleep apnea had a higher percentage of influenza vaccination for their season of illness (75% of patients) compared to patients who were adherent to CPAP (56% of patients), although the difference in vaccination was not statistically significant. CONCLUSIONS: Patients with OSA who did not use CPAP appear to have greater rates of hospitalization from acute influenza infection, despite having a higher trend of influenza vaccination compared to patients who were adherent to CPAP.

The Use of Intravenous Lidocaine for the Management of Acute Pain Secondary to Traumatic Ankle Injury: A Case Report.

Sports-related injuries are a frequent cause of visits to the emergency department (ED) across the United States. A majority of these injuries affect the lower extremities with the ankle as the most frequently reported site. Most sports-related injuries are not severe enough to require inpatient hospitalization; however, they often lead to acute distress and pain which require prompt treatment with analgesics. Approximately 22% of patients who presented to the ED required pharmacotherapy for acute pain management. Opioids have been traditionally used for the management of severe acute pain in the ED; however, there are growing concerns for opioid overuse and misuse. As a result, there is growing controversy regarding the appropriate selection of analgesic agents, optimal dosing, and need for outpatient therapy which has contributed to changes in prescribing patterns of opioids in the ED. Lidocaine, a class 1b antiarrhythmic, has been utilized as an analgesic agent. Its use has been documented for the management of intractable chronic pain caused by cancer, stroke, neuropathies, or nephrolithiasis. However, literature describing the use of intravenous lidocaine for the management of acute pain secondary to trauma is limited to a single case series. This case report describes the use of intravenous lidocaine in a 17-year-old male who presented to the ED in acute distress secondary to ankle dislocation and fracture. This report serves to describe additional clinical experience with intravenous lidocaine for the management of acute pain secondary to ankle fracture in the emergency department.

Frontal and temporal contributions to understanding the iconic co-speech gestures that accompany speech.

In everyday conversation, listeners often rely on a speaker's gestures to clarify any ambiguities in the verbal message. Using fMRI during naturalistic story comprehension, we examined which brain regions in the listener are sensitive to speakers' iconic gestures. We focused on iconic gestures that contribute information not found in the speaker's talk, compared with those that convey information redundant with the speaker's talk. We found that three regions-left inferior frontal gyrus triangular (IFGTr) and opercular (IFGOp) portions, and left posterior middle temporal gyrus (MTGp)--responded more strongly when gestures added information to nonspecific language, compared with when they conveyed the same information in more specific language; in other words, when gesture disambiguated speech as opposed to reinforced it. An increased BOLD response was not found in these regions when the nonspecific language was produced without gesture, suggesting that IFGTr, IFGOp, and MTGp are involved in integrating semantic information across gesture and speech. In addition, we found that activity in the posterior superior temporal sulcus (STSp), previously thought to be involved in gesture-speech integration, was not sensitive to the gesture-speech relation. Together, these findings clarify the neurobiology of gesture-speech integration and contribute to an emerging picture of how listeners glean meaning from gestures that accompany speech.