[Studying spasmolytic activity of imidazo[1,2-a]azepinium derivatives on isolated strips of rat bladder].

We have performed screening tests for imidazo[1,2-a]azepine derivatives by studying their antispasmodic activity on the isolated strips of urinary bladder of female rats. Test compounds showed the ability to reduce the basal tone of bladder stripes on the background of hyperpotassium constriction (40 mM KCl).

[Comparative study of the effects of new fluorine-containing pinacidyl analogs on bladder contractile function and vessel tone].

The effects of four new fluorine-containing pinacidyl analogs (FPs) on the bladder contractile function in vitro and in vivo, and on the vessel tone in vitro were examined. All the four drugs produced a concentration-dependent relaxation of isolated rat detrusor strips and isolated aorta rings. The contractility inhibition effect of compound FP-5 was decreased by preliminary glibenclamide perfusion. This compound also effectively inhibited bladder contractility function in vivo.

[Histamine. Its action on the heart and vessels]. / Gistamin. Deistvie na serdtse i sosudy.

The literature data on the effect of histamine on the heart and vessels in different species of animals and man were analyzed. Nonheterogeneity of histamine effect can be presumably explained by a strong representation of various types of receptors to which this biogenic amine is bound (H1, H2, H3) in the organs and tissues, their unequal location on the pre- and postsynaptic membrane, the differences in their physiological functions.

[Histamine metabolism and its role in central nervous system function]. / Obmen gistamina i ego rol' v funktsionirovanii TsNS.

The present day data concerning biosynthesis, storage, release and inactivation of histamine in the brain of mammals are given. The possibility to regulate histamine of the action of physiologically active substances is discussed.

[Cardiovascular effects of histamine mediated by H1- and H2-receptors]. / Serdechno-sosudistye éffekty gistamina, oposredovannye cherez H1- i H2-retseptory.

Histamine was found to suppress the myocardial contractile function, to decrease systemic arterial blood pressure and to exert a positive chronotropic effect in unanesthetized dogs. A preliminary blockade of H1-receptors prevented the hypotensive effect of histamine, blockade of H2-receptors prevented the development of the positive chronotropic effect.

[Anti-inflammatory, analgesic and antipyretic activity of pyrimidant]. / Protivovospalitel'naia, anal'geziruiushchaia i zharoponizhaiushchaia aktivnost' pirimidanta.

In experiments on rats with different models of pathology it was demonstrated that a new non-steroidal anti-inflammatory drug pyrimidant exerts pronounced anti-inflammatory, analgesic and antipyretic effects. In some cases its activity exceeds that of indomethacin, brufen, butadione, mefenamic acid, sodium salicylate.