[The effect of sulpiride on intensity of gastroesophageal reflux]. / Wplyw sulpirydu na intensywnosc refluksu zoladkowo-przelykowego.

UNLABELLED: Drugs inhibiting gastric acid secretion are most commonly used in a long-term treatment of GERD. In a number of patients their therapeutic effects are not satisfactory enough. For that reason other medicines are added as a concomitant therapy, e.g., prokinetics. Adverse drug reactions of widely available prokinetics limit their application and inspire us to search for different pharmacological compounds THE AIM OF THE STUDY: To evaluate if sulpiride can prevent episodes of gastroesophageal refluxes. MATERIALS AND METHODS: The study comprised 25 men, aged 26-58 years, suffering from GERD, with erosive oesophagitis of A and B grades according to Los Angeles classification. In each subject 24-hour oesophageal pH-metry (Digitrapper Marc III, Synectics) was performed three times: prior to sulpiride administration, after the first two doses of 50 mg and after 6 weeks of treatment in the daily dose of 2 x 50 mg. On the day of the measurements patients remained on a standard liquid diet (Nutridrink 3 x 400 ml). RESULTS: The initial reflux index prior to the drug administration was 18.8 +/- 10.7; after the first two doses it was 13.6 +/- 9.9 (p = 0.020), whereas after 6 weeks of therapy it was 16.3 +/- 10.1 (p = 0.034). The De Meester scores were: 74.0 +/- 52.3; 53, 4 +/- 41.9 (p = 0.002) and 56, 6 +/- 38.7 (p = 0.014) respectively. CONCLUSIONS: Sulpiride reduces intensity of gastroesophageal refux. Sulpiride can be considered in the combined treatment of GERD.

[24-hour urinary 5-hydroxyindole acetic acid excretion in patients with ulcerative colitis]. / Wydalanie kwasu 5-hydroksyindolooctowego z moczem u osób z wrzodziejacym zapaleniem jelita grubego.

UNLABELLED: The experimental data show that in mucosal injury of the alimentary system serotonin metabolism and secretion is disturbed. Such suggestions are also drawn in discussions concerning pathogenesis of ulcerative colitis. THE AIM OF THE STUDY: To perform a quantitative evaluation of 24-hour urine excretion of a major serotonin metabolite-5-hydroxyindole acetic acid (5-HIAA) in patients with ulcerative colitis (UC). MATERIAL AND METHODS: The studied group comprised 50 patients with exacerbated UC, aged 21-56 years. Among them 25 had mild and 25 severe exacerbation according to Trulove's and Witts criteria. The control group comprised 25 healthy persons. On the study day the patients remained on standard liquid diet--Nutrdrink 3 x 400 ml with the caloric value of 1800 kcal. 5-HIAA concentration was measured by ELISA method applying IBL antibodies (RE 59131), and the results were presented in mg/dl and then the value of 24-hour urine excretion was calculated. Results. In the group o patients with severely exacerbated UC 5-HIAA excretion was significantly lower that in healthy volunteers--1.66 +/- 0.98 mg/24 hi 5.77 +/- 0.46 mg/24 respectively (p < 0.05). The results of 5-HIAA excretion showed positive correlation with serum albumin concentration. In the group of patients with mild colitis such significant changes and correlations were not observed. CONCLUSIONS: (1) In severe exacerbations of UC serotonin metabolism is largely changed. (2) 24-hour serotonin excretion can have a predictive value in UC.